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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EN1_ESX1_GBX1
Z-value: 1.11
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Transcription factors associated with EN1_ESX1_GBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GBX1 | hg38_v1_chr7_-_151167692_151167697 | 0.42 | 1.4e-10 | Click! |
| EN1 | hg38_v1_chr2_-_118847638_118847654 | 0.11 | 1.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EN1_ESX1_GBX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111923722 Show fit | 41.48 |
ENST00000527950.5
|
crystallin alpha B |
|
| chr3_+_111998739 Show fit | 35.40 |
ENST00000393917.6
ENST00000273368.8 |
transgelin 3 |
|
| chr3_+_111999189 Show fit | 34.94 |
ENST00000455401.6
|
transgelin 3 |
|
| chr3_+_111999326 Show fit | 34.14 |
ENST00000494932.1
|
transgelin 3 |
|
| chr19_+_44905785 Show fit | 31.07 |
ENST00000446996.5
ENST00000252486.9 ENST00000434152.5 |
apolipoprotein E |
|
| chr3_+_111998915 Show fit | 31.05 |
ENST00000478951.6
|
transgelin 3 |
|
| chrX_-_13817027 Show fit | 30.79 |
ENST00000493677.5
ENST00000355135.6 ENST00000316715.9 |
glycoprotein M6B |
|
| chr11_-_117876719 Show fit | 30.10 |
ENST00000529335.6
ENST00000260282.8 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117877463 Show fit | 29.61 |
ENST00000527717.5
|
FXYD domain containing ion transport regulator 6 |
|
| chr12_-_6124662 Show fit | 29.00 |
ENST00000261405.10
|
von Willebrand factor |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 83.4 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 7.1 | 71.3 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 69.7 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.6 | 54.0 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 9.3 | 46.5 | GO:1901628 | positive regulation of postsynaptic membrane organization(GO:1901628) |
| 1.5 | 40.0 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 4.0 | 35.8 | GO:0061669 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 2.0 | 34.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.6 | 32.6 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.2 | 31.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 129.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 80.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.4 | 67.8 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 62.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 1.1 | 62.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 3.0 | 48.4 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 2.6 | 41.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 5.1 | 35.6 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 7.8 | 31.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.3 | 29.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 144.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.3 | 85.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.1 | 70.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.3 | 53.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.7 | 50.1 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.6 | 49.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 43.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 36.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 7.1 | 35.6 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 5.3 | 31.6 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 16.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.5 | 15.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 15.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.5 | 14.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 13.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 13.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 12.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 12.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 9.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 36.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.7 | 29.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 1.2 | 26.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 17.8 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.4 | 16.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 15.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 14.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 13.8 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.5 | 13.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 11.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |