ISMARA results: EN2_GBX2

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for EN2_GBX2_LBX2

Z-value: 0.61

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol	Gene ID	Gene Info
EN2 Ensembl NCBI GeneCards UniProt	ENSG00000164778.4	EN2
GBX2 Ensembl NCBI GeneCards UniProt	ENSG00000168505.7	GBX2
LBX2 Ensembl NCBI GeneCards UniProt	ENSG00000179528.16	LBX2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EN2	hg38_v1_chr7_+_155458129_155458129	0.28	3.0e-05	Click!
GBX2	hg38_v1_chr2_-_236168376_236168395	0.20	3.7e-03	Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr2_-_223602284 Show fit	12.69	ENST00000421386.1 ENST00000305409.3 ENST00000433889.1	SCG2 Ensembl NCBI GeneCards UniProt Show fit	secretogranin II
chr3_+_111999189 Show fit	11.61	ENST00000455401.6	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr3_+_111999326 Show fit	11.43	ENST00000494932.1	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr3_+_111998739 Show fit	11.37	ENST00000393917.6 ENST00000273368.8	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr3_+_115623502 Show fit	10.96	ENST00000305124.11 ENST00000393780.3	GAP43 Ensembl NCBI GeneCards UniProt Show fit	growth associated protein 43
chr16_-_29899532 Show fit	10.80	ENST00000308713.9 ENST00000617533.5	SEZ6L2 Ensembl NCBI GeneCards UniProt Show fit	seizure related 6 homolog like 2
chr3_+_111998915 Show fit	10.74	ENST00000478951.6	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr5_+_141484997 Show fit	9.34	ENST00000617094.1 ENST00000306593.2 ENST00000610539.1 ENST00000618371.4	PCDHGC4 Ensembl NCBI GeneCards UniProt Show fit	protocadherin gamma subfamily C, 4
chr7_+_70596078 Show fit	9.31	ENST00000644506.1	AUTS2 Ensembl NCBI GeneCards UniProt Show fit	activator of transcription and developmental regulator AUTS2
chr4_+_112860981 Show fit	9.00	ENST00000671704.1	ANK2 Ensembl NCBI GeneCards UniProt Show fit	ankyrin 2

Showing 1 to 10 of 135 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	41.1	GO:0000122	negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
2.7	26.6	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2	15.5	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2	14.4	GO:0006458	'de novo' protein folding(GO:0006458)
1.5	13.1	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.9	12.7	GO:0048245	eosinophil chemotaxis(GO:0048245)
1.2	11.0	GO:0016198	axon choice point recognition(GO:0016198)
0.4	9.8	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.1	9.5	GO:0006757	glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
3.1	9.3	GO:0098582	innate vocalization behavior(GO:0098582)

Showing 1 to 10 of 65 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	45.1	GO:0043209	myelin sheath(GO:0043209)
0.5	26.6	GO:0031430	M band(GO:0031430)
0.0	14.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	13.1	GO:0048786	presynaptic active zone(GO:0048786)
0.6	12.7	GO:0031045	dense core granule(GO:0031045)
0.2	11.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
1.8	11.0	GO:0032584	growth cone membrane(GO:0032584)
1.4	9.5	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.1	8.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	7.9	GO:0005925	focal adhesion(GO:0005925)

Showing 1 to 10 of 45 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	42.1	GO:0051015	actin filament binding(GO:0051015)
0.4	26.6	GO:0030507	spectrin binding(GO:0030507)
0.2	15.9	GO:0017080	sodium channel regulator activity(GO:0017080)
2.3	13.6	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.1	13.1	GO:0044325	ion channel binding(GO:0044325)
1.2	11.0	GO:0035727	lysophosphatidic acid binding(GO:0035727)
1.9	9.5	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	7.7	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.8	7.4	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.2	7.1	GO:0019865	immunoglobulin binding(GO:0019865)

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	7.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	5.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	4.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	3.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	2.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	1.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	1.8	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.4	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	8.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	2.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	2.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	2.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	1.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	1.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.1	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	1.0	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	1.0	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi

Showing 1 to 10 of 16 entries

Results for EN2_GBX2_LBX2

Z-value: 0.61

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Activity-expression correlation:

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: