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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EOMES
Z-value: 1.09
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Transcription factors associated with EOMES
Network of associatons between targets according to the STRING database.
First level regulatory network of EOMES
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 35.2 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 2.5 | 34.9 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 2.0 | 30.3 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 1.5 | 29.1 | GO:0000022 | mitotic spindle elongation(GO:0000022) |
| 2.1 | 27.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 4.5 | 27.0 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.7 | 25.0 | GO:0034080 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 4.1 | 24.8 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 6.0 | 23.9 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.4 | 23.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 3.5 | 31.6 | GO:0097452 | GAIT complex(GO:0097452) |
| 3.8 | 30.3 | GO:0000796 | condensin complex(GO:0000796) |
| 1.3 | 27.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 1.6 | 25.6 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.3 | 24.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 1.8 | 24.0 | GO:0042555 | MCM complex(GO:0042555) |
| 0.4 | 23.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 1.0 | 23.1 | GO:0046930 | pore complex(GO:0046930) |
| 1.6 | 23.0 | GO:0070938 | contractile ring(GO:0070938) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 82.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.8 | 38.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.5 | 32.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.9 | 31.6 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.2 | 28.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 2.6 | 25.6 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 2.7 | 24.1 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 1.1 | 23.9 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.5 | 23.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 2.9 | 23.1 | GO:0015288 | porin activity(GO:0015288) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 54.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 45.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 38.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.7 | 30.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 27.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 25.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.5 | 16.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 13.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 12.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.3 | 12.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 25.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 1.1 | 25.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 1.6 | 24.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.3 | 23.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 23.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.2 | 18.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 18.0 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.4 | 17.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.7 | 14.7 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.4 | 14.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |