ISMARA results: EP300

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EP300

Z-value: 1.05

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Transcription factors associated with EP300

Gene Symbol	Gene ID	Gene Info
EP300 Ensembl NCBI GeneCards UniProt	ENSG00000100393.14	EP300

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EP300	hg38_v1_chr22_+_41092585_41092633, hg38_v1_chr22_+_41092869_41093005	-0.27	7.3e-05	Click!

Activity profile of EP300 motif

Sorted Z-values of EP300 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EP300

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Promoter	Score	Transcript	Gene	Gene Info
chr12_+_6199715 Show fit	16.79	ENST00000382518.6 ENST00000642746.1 ENST00000538834.6	CD9 Ensembl NCBI GeneCards UniProt Show fit	CD9 molecule
chr14_-_68979251 Show fit	16.40	ENST00000438964.6 ENST00000679147.1	ACTN1 Ensembl NCBI GeneCards UniProt Show fit	actinin alpha 1
chr14_-_68979274 Show fit	16.04	ENST00000394419.9	ACTN1 Ensembl NCBI GeneCards UniProt Show fit	actinin alpha 1
chr14_-_68979314 Show fit	15.86	ENST00000684713.1 ENST00000683198.1 ENST00000684598.1 ENST00000682331.1 ENST00000682291.1 ENST00000683342.1	ACTN1 Ensembl NCBI GeneCards UniProt Show fit	actinin alpha 1
chr12_+_6200327 Show fit	15.77	ENST00000610354.5	CD9 Ensembl NCBI GeneCards UniProt Show fit	CD9 molecule
chr14_-_68979076 Show fit	15.70	ENST00000538545.6 ENST00000684639.1	ACTN1 Ensembl NCBI GeneCards UniProt Show fit	actinin alpha 1
chr12_+_6200351 Show fit	15.46	ENST00000679331.1 ENST00000382519.9 ENST00000009180.10 ENST00000536586.7	CD9 Ensembl NCBI GeneCards UniProt Show fit	CD9 molecule
chr14_-_68979436 Show fit	15.42	ENST00000193403.10	ACTN1 Ensembl NCBI GeneCards UniProt Show fit	actinin alpha 1
chr10_-_125161019 Show fit	15.06	ENST00000411419.6	CTBP2 Ensembl NCBI GeneCards UniProt Show fit	C-terminal binding protein 2
chrX_+_23667461 Show fit	12.33	ENST00000379341.9 ENST00000379331.3	PRDX4 Ensembl NCBI GeneCards UniProt Show fit	peroxiredoxin 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	79.4	GO:0051639	actin filament network formation(GO:0051639)
4.0	48.0	GO:0009414	response to water deprivation(GO:0009414)
6.0	42.2	GO:0030421	defecation(GO:0030421)
3.5	35.2	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
5.0	19.8	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
1.9	19.0	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
1.7	14.9	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
2.3	13.5	GO:0060356	leucine import(GO:0060356)
3.1	12.3	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
1.4	12.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)

Showing 1 to 10 of 197 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	79.4	GO:0005916	fascia adherens(GO:0005916)
1.3	48.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
4.4	35.2	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.3	31.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.2	22.4	GO:0005882	intermediate filament(GO:0005882)
0.6	19.8	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
1.2	19.0	GO:0097470	ribbon synapse(GO:0097470)
0.0	18.9	GO:0031012	extracellular matrix(GO:0031012)
0.1	15.5	GO:0005796	Golgi lumen(GO:0005796)
0.1	13.5	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)

Showing 1 to 10 of 90 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	79.4	GO:0017166	vinculin binding(GO:0017166)
0.3	43.6	GO:0008201	heparin binding(GO:0008201)
0.2	40.8	GO:0005178	integrin binding(GO:0005178)
4.4	35.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
1.2	21.1	GO:0019215	intermediate filament binding(GO:0019215)
0.1	20.5	GO:0004896	cytokine receptor activity(GO:0004896)
0.1	20.1	GO:0044325	ion channel binding(GO:0044325)
2.7	19.0	GO:0016618	hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1	18.7	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	16.5	GO:0051219	phosphoprotein binding(GO:0051219)

Showing 1 to 10 of 145 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	121.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.4	57.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.6	49.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	28.0	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	16.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	14.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.3	13.8	PID S1P S1P2 PATHWAY	S1P2 pathway
0.2	10.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	9.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	8.1	PID TGFBR PATHWAY	TGF-beta receptor signaling

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	89.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.4	53.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.6	35.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	21.1	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4	19.8	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.4	17.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	16.8	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.4	12.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	10.4	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.1	8.6	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions

Showing 1 to 10 of 58 entries

Results for EP300

Z-value: 1.05

Motif logo

Transcription factors associated with EP300

Activity-expression correlation:

Activity profile of EP300 motif

Sorted Z-values of EP300 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EP300

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: