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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ERG
Z-value: 1.68
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Transcription factors associated with ERG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ERG | hg38_v1_chr21_-_38661694_38661788, hg38_v1_chr21_-_38498415_38498519 | 0.41 | 2.7e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ERG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 109.3 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.6 | 77.1 | GO:0002455 | humoral immune response mediated by circulating immunoglobulin(GO:0002455) |
| 1.1 | 71.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 3.5 | 69.7 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.3 | 68.2 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 22.6 | 67.7 | GO:1902846 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 16.2 | 64.6 | GO:0002357 | defense response to tumor cell(GO:0002357) |
| 1.8 | 59.7 | GO:0045730 | respiratory burst(GO:0045730) |
| 2.3 | 49.5 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 2.0 | 48.8 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 992.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.8 | 106.7 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 16.9 | 101.5 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 1.1 | 100.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 99.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 98.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 95.2 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 6.8 | 67.8 | GO:0044194 | cytolytic granule(GO:0044194) |
| 22.6 | 67.7 | GO:0061673 | cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673) |
| 0.6 | 61.3 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 358.0 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.8 | 195.7 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.2 | 110.7 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 12.1 | 109.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.4 | 109.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 15.0 | 105.0 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.8 | 87.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 8.3 | 82.8 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.3 | 74.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.5 | 64.7 | GO:0022829 | wide pore channel activity(GO:0022829) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 208.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.0 | 190.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 2.8 | 111.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.6 | 109.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.5 | 105.3 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.9 | 95.1 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.2 | 84.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.9 | 74.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.6 | 72.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.2 | 62.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 376.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.4 | 190.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.8 | 145.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 87.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.9 | 80.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.0 | 78.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 5.2 | 68.1 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 4.4 | 60.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.5 | 53.0 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.8 | 52.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |