ISMARA results: ESR1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ESR1

Z-value: 1.63

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Transcription factors associated with ESR1

Gene Symbol	Gene ID	Gene Info
ESR1 Ensembl NCBI GeneCards UniProt	ENSG00000091831.24	ESR1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ESR1	hg38_v1_chr6_+_151807674_151807692	0.26	9.7e-05	Click!

Activity profile of ESR1 motif

Sorted Z-values of ESR1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ESR1

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Promoter	Score	Transcript	Gene	Gene Info
chr22_+_22758698 Show fit	51.15	ENST00000390312.2	IGLV2-14 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-14
chr22_+_22906342 Show fit	34.34	ENST00000390325.2	IGLC3 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr22_+_22899481 Show fit	32.92	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda joining 2
chr2_-_89100352 Show fit	32.20	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-16
chr2_-_88992903 Show fit	31.08	ENST00000495489.1	IGKV1-8 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-8
chr22_+_22904850 Show fit	30.32	ENST00000390324.2	IGLJ3 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda joining 3
chr22_+_22895368 Show fit	29.80	ENST00000390321.2	IGLC1 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 1
chr22_+_22900976 Show fit	28.90	ENST00000390323.2	IGLC2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 2
chr2_-_89213917 Show fit	28.51	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-27
chr14_-_105588322 Show fit	23.05	ENST00000497872.4 ENST00000390539.2	IGHA2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant alpha 2 (A2m marker)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	393.4	GO:0006958	complement activation, classical pathway(GO:0006958)
1.0	169.4	GO:0002377	immunoglobulin production(GO:0002377)
0.3	92.1	GO:0002250	adaptive immune response(GO:0002250)
4.8	43.3	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.4	38.6	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.5	32.9	GO:0006953	acute-phase response(GO:0006953)
0.4	30.2	GO:0006968	cellular defense response(GO:0006968)
9.3	28.0	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
1.0	23.7	GO:0006068	ethanol catabolic process(GO:0006068)
3.7	22.4	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)

Showing 1 to 10 of 268 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	229.3	GO:0005615	extracellular space(GO:0005615)
0.9	169.4	GO:0072562	blood microparticle(GO:0072562)
1.7	83.6	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
14.4	43.2	GO:0071750	dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752)
0.4	30.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	27.0	GO:0043202	lysosomal lumen(GO:0043202)
0.2	19.9	GO:0032580	Golgi cisterna membrane(GO:0032580)
3.1	18.8	GO:0097013	phagocytic vesicle lumen(GO:0097013)
0.3	18.0	GO:0015030	Cajal body(GO:0015030)
0.7	17.1	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 109 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	608.7	GO:0003823	antigen binding(GO:0003823)
0.2	42.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.4	37.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	35.3	GO:0017137	Rab GTPase binding(GO:0017137)
9.3	28.0	GO:0008859	exoribonuclease II activity(GO:0008859)
5.5	21.9	GO:0032810	sterol response element binding(GO:0032810)
0.7	21.8	GO:0001530	lipopolysaccharide binding(GO:0001530)
4.7	18.8	GO:0004306	ethanolamine-phosphate cytidylyltransferase activity(GO:0004306)
0.7	18.0	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
2.0	17.8	GO:0043426	MRF binding(GO:0043426)

Showing 1 to 10 of 208 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	38.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	31.5	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.7	29.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.3	17.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.2	14.3	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	13.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	12.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	12.8	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	9.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	9.5	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 53 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	32.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	30.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.6	27.2	REACTOME AMYLOIDS	Genes involved in Amyloids
1.3	21.0	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	20.0	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	18.5	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.4	18.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.8	17.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.2	16.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.7	15.9	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 87 entries

Results for ESR1

Z-value: 1.63

Motif logo

Transcription factors associated with ESR1

Activity-expression correlation:

Activity profile of ESR1 motif

Sorted Z-values of ESR1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ESR1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: