Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ESRRA_ESR2
Z-value: 2.25
Motif logo
Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg38_v1_chr11_+_64306227_64306446 | 0.42 | 5.7e-11 | Click! |
| ESR2 | hg38_v1_chr14_-_64294364_64294410 | 0.29 | 1.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_22895368 Show fit | 103.46 |
ENST00000390321.2
|
immunoglobulin lambda constant 1 |
|
| chr22_+_22922594 Show fit | 99.59 |
ENST00000390331.3
|
immunoglobulin lambda constant 7 |
|
| chr22_+_22906342 Show fit | 90.60 |
ENST00000390325.2
|
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
|
| chr14_-_105743032 Show fit | 69.02 |
ENST00000390548.6
ENST00000390549.6 ENST00000390542.6 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
|
| chr22_+_22899481 Show fit | 61.62 |
ENST00000390322.2
|
immunoglobulin lambda joining 2 |
|
| chr14_-_105708627 Show fit | 60.97 |
ENST00000641837.1
ENST00000390547.3 |
immunoglobulin heavy constant alpha 1 |
|
| chr6_+_33075952 Show fit | 49.82 |
ENST00000418931.7
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr22_+_22900976 Show fit | 48.25 |
ENST00000390323.2
|
immunoglobulin lambda constant 2 |
|
| chr22_+_22887780 Show fit | 46.50 |
ENST00000532223.2
ENST00000526893.6 ENST00000531372.1 |
immunoglobulin lambda like polypeptide 5 |
|
| chr14_-_105626066 Show fit | 39.97 |
ENST00000641978.1
ENST00000390543.3 |
immunoglobulin heavy constant gamma 4 (G4m marker) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 714.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.1 | 264.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.3 | 190.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.8 | 166.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 1.6 | 164.6 | GO:0031295 | T cell costimulation(GO:0031295) |
| 11.5 | 103.9 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 4.7 | 98.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.2 | 85.7 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 5.9 | 76.5 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 1.2 | 69.2 | GO:0006953 | acute-phase response(GO:0006953) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.3 | 637.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.4 | 498.5 | GO:0005615 | extracellular space(GO:0005615) |
| 2.6 | 448.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 308.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 9.1 | 173.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.0 | 144.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.6 | 134.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 32.4 | 97.1 | GO:0071750 | dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) |
| 1.0 | 78.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.8 | 65.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.8 | 769.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 3.8 | 556.1 | GO:0003823 | antigen binding(GO:0003823) |
| 1.4 | 317.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 5.4 | 211.9 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.7 | 174.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 110.5 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.6 | 109.6 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.7 | 81.5 | GO:0005179 | hormone activity(GO:0005179) |
| 6.3 | 56.6 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 12.5 | 50.1 | GO:0033897 | ribonuclease T2 activity(GO:0033897) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 243.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.0 | 212.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 1.8 | 137.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.7 | 116.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.4 | 116.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.6 | 114.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.3 | 89.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 69.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.3 | 55.0 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.6 | 47.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 186.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 8.9 | 186.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 4.1 | 78.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.2 | 77.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.7 | 69.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 2.9 | 62.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.7 | 61.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 3.3 | 59.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 55.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.9 | 54.8 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |