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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ESRRB_ESRRG
Z-value: 2.52
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Transcription factors associated with ESRRB_ESRRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRG | hg38_v1_chr1_-_217076889_217076997 | -0.54 | 6.4e-18 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRB_ESRRG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_144095054 Show fit | 108.81 |
ENST00000318911.5
|
cytochrome c1 |
|
| chr2_-_175181663 Show fit | 85.47 |
ENST00000392541.3
ENST00000284727.9 ENST00000409194.5 |
ATP synthase membrane subunit c locus 3 |
|
| chr1_+_40988513 Show fit | 67.94 |
ENST00000649215.1
|
CTP synthase 1 |
|
| chr20_-_63499074 Show fit | 65.50 |
ENST00000217182.6
ENST00000642899.1 |
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr15_-_72231583 Show fit | 50.14 |
ENST00000566809.1
ENST00000567087.5 ENST00000569050.1 ENST00000568883.5 |
pyruvate kinase M1/2 |
|
| chr15_-_72231113 Show fit | 48.91 |
ENST00000565154.6
ENST00000565184.6 ENST00000335181.10 |
pyruvate kinase M1/2 |
|
| chr10_+_79347491 Show fit | 43.69 |
ENST00000448165.1
|
peptidylprolyl isomerase F |
|
| chr7_-_29990113 Show fit | 42.22 |
ENST00000426154.5
ENST00000421434.5 ENST00000434476.6 |
secernin 1 |
|
| chr14_-_58427114 Show fit | 41.70 |
ENST00000556007.6
|
translocase of inner mitochondrial membrane 9 |
|
| chr14_-_103521342 Show fit | 41.42 |
ENST00000553610.5
|
creatine kinase B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 304.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 10.8 | 204.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 1.8 | 131.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 32.1 | 128.5 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 11.8 | 106.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 12.4 | 99.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 4.7 | 88.7 | GO:0075713 | establishment of integrated proviral latency(GO:0075713) |
| 2.2 | 88.2 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 7.5 | 82.4 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 13.7 | 82.2 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 442.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 4.5 | 353.3 | GO:0098800 | inner mitochondrial membrane protein complex(GO:0098800) |
| 17.3 | 225.0 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 3.8 | 151.8 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 2.7 | 141.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 11.8 | 129.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 15.7 | 94.1 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.3 | 93.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 10.3 | 92.5 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.3 | 86.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 281.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 7.5 | 217.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.7 | 211.4 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.6 | 135.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 24.8 | 99.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 1.5 | 98.9 | GO:0009055 | electron carrier activity(GO:0009055) |
| 11.9 | 95.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 8.4 | 91.9 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 5.0 | 89.8 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 10.3 | 82.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 256.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.8 | 89.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.4 | 46.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 39.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 2.6 | 36.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.1 | 34.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.5 | 32.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 29.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.4 | 29.5 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.5 | 27.0 | PID IFNG PATHWAY | IFN-gamma pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 781.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 4.3 | 283.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 4.0 | 220.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.6 | 147.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 8.1 | 88.7 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 5.1 | 76.1 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 1.9 | 64.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.3 | 38.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 1.3 | 36.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.9 | 34.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |