Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ETS1
Z-value: 2.21
Motif logo
Transcription factors associated with ETS1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETS1 | hg38_v1_chr11_-_128522189_128522208 | 0.49 | 1.2e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETS1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 240.8 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.4 | 199.5 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.9 | 194.3 | GO:0038093 | Fc receptor signaling pathway(GO:0038093) |
| 2.0 | 176.3 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 5.8 | 122.8 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 2.6 | 116.1 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway(GO:0035666) |
| 6.3 | 113.9 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 2.3 | 111.3 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 2.6 | 108.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 3.1 | 105.8 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 402.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 3.5 | 378.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.9 | 238.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 3.2 | 181.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 8.9 | 178.1 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 26.0 | 155.9 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 1.1 | 132.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.8 | 120.9 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 6.5 | 116.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 1.8 | 114.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 387.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 217.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 22.3 | 155.9 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 2.2 | 136.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 2.7 | 127.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 3.0 | 114.2 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 4.4 | 113.9 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 9.1 | 99.8 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) |
| 1.0 | 97.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 5.3 | 94.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 362.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 3.5 | 328.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 2.7 | 217.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 4.3 | 208.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 4.0 | 167.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.5 | 141.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 1.1 | 131.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.4 | 80.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 1.1 | 75.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 1.1 | 61.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 419.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 3.6 | 271.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.7 | 253.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 3.1 | 205.9 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 3.5 | 186.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.6 | 174.0 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 7.1 | 169.5 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 2.1 | 135.8 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 3.0 | 132.6 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 3.7 | 124.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |