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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ETV1_ERF_FEV_ELF1
Z-value: 2.04
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Transcription factors associated with ETV1_ERF_FEV_ELF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF1 | hg38_v1_chr13_-_41019289_41019343 | -0.71 | 2.7e-35 | Click! |
| ERF | hg38_v1_chr19_-_42255119_42255137 | 0.26 | 7.6e-05 | Click! |
| ETV1 | hg38_v1_chr7_-_13988863_13988891 | 0.21 | 2.0e-03 | Click! |
| FEV | hg38_v1_chr2_-_218985176_218985205 | -0.01 | 8.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV1_ERF_FEV_ELF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 296.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 2.2 | 175.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 1.7 | 148.1 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.9 | 127.9 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 3.0 | 116.4 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 3.6 | 106.7 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.3 | 98.1 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 6.3 | 94.6 | GO:0000338 | protein deneddylation(GO:0000338) |
| 4.6 | 91.5 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 4.2 | 88.1 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 204.5 | GO:0044429 | mitochondrial part(GO:0044429) |
| 0.7 | 201.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 4.3 | 171.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 3.1 | 166.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 11.1 | 110.5 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.6 | 97.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 96.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 5.3 | 95.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.3 | 88.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 6.2 | 86.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 249.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.4 | 168.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.4 | 143.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 3.5 | 119.6 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 1.8 | 103.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 2.8 | 102.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 3.2 | 91.5 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.9 | 89.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 1.4 | 84.5 | GO:0004527 | exonuclease activity(GO:0004527) |
| 9.4 | 84.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 174.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 3.9 | 104.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 1.3 | 75.3 | PID ATR PATHWAY | ATR signaling pathway |
| 2.4 | 72.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 2.3 | 66.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 1.2 | 65.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.6 | 57.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 53.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.6 | 48.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 1.1 | 47.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 271.6 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 1.0 | 178.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 3.2 | 174.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 2.0 | 164.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.7 | 159.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 3.4 | 151.2 | REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | Genes involved in Formation of the HIV-1 Early Elongation Complex |
| 2.4 | 100.4 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 3.9 | 96.8 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 1.7 | 93.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 3.4 | 89.6 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |