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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ETV2
Z-value: 1.07
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Transcription factors associated with ETV2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV2 | hg38_v1_chr19_+_35641728_35641793 | 0.11 | 9.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 48.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.4 | 33.4 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 1.4 | 27.3 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.6 | 19.8 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.2 | 18.6 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 3.5 | 17.4 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.1 | 15.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.6 | 13.9 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 1.0 | 13.8 | GO:0006930 | substrate-dependent cell migration, cell extension(GO:0006930) |
| 2.2 | 13.4 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 32.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.9 | 26.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.6 | 24.3 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.4 | 23.8 | GO:0002102 | podosome(GO:0002102) |
| 1.8 | 20.0 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 1.4 | 18.6 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.8 | 17.8 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 16.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 1.2 | 16.0 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 3.1 | 15.6 | GO:0032449 | CBM complex(GO:0032449) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.0 | 27.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.1 | 23.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 22.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 21.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.5 | 19.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.7 | 18.8 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.4 | 15.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.3 | 15.5 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 1.0 | 13.9 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.9 | 25.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.5 | 25.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 18.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.6 | 17.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.5 | 15.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.3 | 14.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 13.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 12.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 11.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 25.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.9 | 22.4 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.8 | 21.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 18.9 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 1.5 | 17.4 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.3 | 13.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 12.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 11.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.5 | 10.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |