ISMARA results: ETV4

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ETV4_ETS2

Z-value: 1.00

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Transcription factors associated with ETV4_ETS2

Gene Symbol	Gene ID	Gene Info
ETV4 Ensembl NCBI GeneCards UniProt	ENSG00000175832.13	ETV4
ETS2 Ensembl NCBI GeneCards UniProt	ENSG00000157557.13	ETS2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ETV4	hg38_v1_chr17_-_43545707_43545732	0.23	6.8e-04	Click!
ETS2	hg38_v1_chr21_+_38805968_38805983, hg38_v1_chr21_+_38805895_38805951, hg38_v1_chr21_+_38805165_38805217	0.07	3.2e-01	Click!

Activity profile of ETV4_ETS2 motif

Sorted Z-values of ETV4_ETS2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV4_ETS2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr11_-_236821 Show fit	26.71	ENST00000529382.5 ENST00000528469.1	SIRT3 Ensembl NCBI GeneCards UniProt Show fit	sirtuin 3
chr12_-_6124662 Show fit	17.97	ENST00000261405.10	VWF Ensembl NCBI GeneCards UniProt Show fit	von Willebrand factor
chr10_-_15860450 Show fit	17.85	ENST00000277632.8	MINDY3 Ensembl NCBI GeneCards UniProt Show fit	MINDY lysine 48 deubiquitinase 3
chr16_-_31074193 Show fit	17.09	ENST00000300849.5	ZNF668 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 668
chr11_-_46700567 Show fit	16.49	ENST00000311956.9	ARHGAP1 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 1
chr6_+_31652414 Show fit	15.96	ENST00000375918.6 ENST00000375920.8	APOM Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein M
chr5_-_150000632 Show fit	14.62	ENST00000296736.4 ENST00000515406.2	TIGD6 Ensembl NCBI GeneCards UniProt Show fit	tigger transposable element derived 6
chr12_+_53050014 Show fit	14.54	ENST00000314250.11	TNS2 Ensembl NCBI GeneCards UniProt Show fit	tensin 2
chr11_+_46701010 Show fit	14.28	ENST00000311764.3	ZNF408 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 408
chr20_-_49915509 Show fit	13.97	ENST00000289431.10	SPATA2 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	29.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.6	28.2	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.9	27.3	GO:0014850	response to muscle activity(GO:0014850)
2.1	26.7	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.4	22.8	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
4.1	20.3	GO:2000870	oocyte growth(GO:0001555) regulation of progesterone secretion(GO:2000870)
1.0	20.2	GO:0019336	phenol-containing compound catabolic process(GO:0019336)
0.7	18.9	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
3.7	18.4	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
0.6	18.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)

Showing 1 to 10 of 524 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	29.9	GO:0005796	Golgi lumen(GO:0005796)
1.4	26.3	GO:0042589	zymogen granule membrane(GO:0042589)
1.5	20.5	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.7	18.5	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
1.4	18.0	GO:0033093	Weibel-Palade body(GO:0033093)
1.8	17.9	GO:0097443	sorting endosome(GO:0097443)
0.1	17.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.3	17.0	GO:0005881	cytoplasmic microtubule(GO:0005881)
4.0	16.0	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.2	15.9	GO:0032588	trans-Golgi network membrane(GO:0032588)

Showing 1 to 10 of 225 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	29.5	GO:0017136	NAD-dependent histone deacetylase activity(GO:0017136)
0.3	29.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.3	27.1	GO:0005507	copper ion binding(GO:0005507)
8.8	26.3	GO:0035375	zymogen binding(GO:0035375)
0.3	26.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.4	20.9	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.2	20.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.3	19.2	GO:0030507	spectrin binding(GO:0030507)
0.3	18.8	GO:0070412	R-SMAD binding(GO:0070412)
2.0	18.2	GO:0016206	catechol O-methyltransferase activity(GO:0016206)

Showing 1 to 10 of 322 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	57.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	29.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.3	25.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.3	24.1	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	23.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.6	21.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.7	19.6	PID ARF 3PATHWAY	Arf1 pathway
0.3	18.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	18.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	17.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 73 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	26.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	20.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.1	18.9	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	17.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	16.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	16.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.2	16.2	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.4	15.9	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	14.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.4	13.8	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling

Showing 1 to 10 of 113 entries

Results for ETV4_ETS2

Z-value: 1.00

Motif logo

Transcription factors associated with ETV4_ETS2

Activity-expression correlation:

Activity profile of ETV4_ETS2 motif

Sorted Z-values of ETV4_ETS2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV4_ETS2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: