Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ETV6
Z-value: 1.51
Motif logo
Transcription factors associated with ETV6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV6 | hg38_v1_chr12_+_11649666_11649751 | -0.24 | 3.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 135.9 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.8 | 96.6 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.7 | 88.1 | GO:0006413 | translational initiation(GO:0006413) |
| 6.2 | 86.6 | GO:0015074 | DNA integration(GO:0015074) |
| 12.7 | 76.3 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 0.7 | 58.8 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 19.5 | 58.4 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 1.4 | 51.8 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.7 | 45.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 43.8 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.7 | 141.6 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 100.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.0 | 98.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.9 | 95.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.4 | 90.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 7.1 | 70.8 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 2.5 | 70.5 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 3.3 | 66.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.5 | 65.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 1.2 | 46.6 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 141.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.0 | 138.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.4 | 99.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.5 | 97.9 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 5.9 | 64.7 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 64.5 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 2.4 | 63.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 7.8 | 62.1 | GO:0070990 | snRNP binding(GO:0070990) |
| 0.8 | 45.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 7.0 | 42.2 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 65.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.9 | 55.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 1.1 | 54.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 35.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.6 | 29.0 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 1.0 | 26.9 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.3 | 25.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 23.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.6 | 17.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.3 | 15.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 179.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 2.2 | 166.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 7.5 | 141.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 8.7 | 95.8 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 2.2 | 92.5 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 4.5 | 67.8 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.9 | 67.8 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
| 1.7 | 58.5 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.7 | 49.4 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.5 | 48.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |