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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ETV7
Z-value: 0.87
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Transcription factors associated with ETV7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV7 | hg38_v1_chr6_-_36387654_36387689 | -0.02 | 8.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 12.6 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 12.2 | GO:0007565 | female pregnancy(GO:0007565) |
| 1.1 | 10.1 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 0.2 | 9.1 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 7.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.3 | 7.6 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.1 | 7.4 | GO:1901998 | toxin transport(GO:1901998) |
| 0.7 | 7.2 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.4 | 6.8 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 6.6 | GO:0010038 | response to metal ion(GO:0010038) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 9.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.9 | 7.6 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 7.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 1.6 | 6.6 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.2 | 6.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 6.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 5.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 5.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.4 | 5.5 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 4.1 | 12.3 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.0 | 7.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 7.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.7 | 6.8 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 6.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 6.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.2 | 6.4 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.2 | 6.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.8 | 6.2 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 8.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 5.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 4.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 4.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 3.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.4 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.2 | 8.4 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.4 | 6.8 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.2 | 6.8 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.3 | 6.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 5.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 5.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.2 | 4.0 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 4.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 3.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |