ISMARA results: EZH2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EZH2

Z-value: 1.98

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Transcription factors associated with EZH2

Gene Symbol	Gene ID	Gene Info
EZH2 Ensembl NCBI GeneCards UniProt	ENSG00000106462.12	EZH2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EZH2	hg38_v1_chr7_-_148883474_148883509	-0.64	7.7e-27	Click!

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

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Promoter	Score	Transcript	Gene	Gene Info
chr11_-_111910888 Show fit	81.90	ENST00000525823.1 ENST00000528961.6	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr11_-_111910790 Show fit	75.23	ENST00000533280.6	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr11_-_111910830 Show fit	73.21	ENST00000526167.5 ENST00000651650.1	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr3_+_115623502 Show fit	57.00	ENST00000305124.11 ENST00000393780.3	GAP43 Ensembl NCBI GeneCards UniProt Show fit	growth associated protein 43
chr17_+_7650916 Show fit	38.08	ENST00000250111.9	ATP1B2 Ensembl NCBI GeneCards UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2
chr7_+_140404034 Show fit	35.88	ENST00000537763.6	RAB19 Ensembl NCBI GeneCards UniProt Show fit	RAB19, member RAS oncogene family
chr6_-_73452124 Show fit	35.65	ENST00000680833.1	CGAS Ensembl NCBI GeneCards UniProt Show fit	cyclic GMP-AMP synthase
chrX_+_70062457 Show fit	35.08	ENST00000338352.3	OTUD6A Ensembl NCBI GeneCards UniProt Show fit	OTU deubiquitinase 6A
chr3_-_195583931 Show fit	32.80	ENST00000343267.8 ENST00000421243.5 ENST00000453131.1	APOD Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein D
chr4_-_16898561 Show fit	32.71	ENST00000515064.5 ENST00000441778.6	LDB2 Ensembl NCBI GeneCards UniProt Show fit	LIM domain binding 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.7	250.5	GO:0007021	tubulin complex assembly(GO:0007021)
1.0	155.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
6.5	110.5	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
3.8	79.0	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
3.1	62.5	GO:2000821	regulation of grooming behavior(GO:2000821)
1.4	61.6	GO:0008038	neuron recognition(GO:0008038)
6.3	57.0	GO:0016198	axon choice point recognition(GO:0016198)
0.8	56.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.8	49.4	GO:0007158	neuron cell-cell adhesion(GO:0007158)
1.6	48.6	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)

Showing 1 to 10 of 393 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.4	279.0	GO:0097512	cardiac myofibril(GO:0097512)
1.0	235.0	GO:0030426	growth cone(GO:0030426)
0.7	120.1	GO:0031225	anchored component of membrane(GO:0031225)
5.5	99.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
2.6	65.5	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.2	64.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
11.8	58.8	GO:0072534	perineuronal net(GO:0072534)
9.5	57.0	GO:0032584	growth cone membrane(GO:0032584)
0.2	47.2	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	44.1	GO:0016021	integral component of membrane(GO:0016021)

Showing 1 to 10 of 167 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.6	257.5	GO:0005212	structural constituent of eye lens(GO:0005212)
0.3	202.9	GO:0005509	calcium ion binding(GO:0005509)
6.3	81.6	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
3.3	65.0	GO:0097109	neuroligin family protein binding(GO:0097109)
2.1	64.4	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
6.3	56.8	GO:0035727	lysophosphatidic acid binding(GO:0035727)
5.4	48.9	GO:0030274	LIM domain binding(GO:0030274)
0.4	48.3	GO:0001618	virus receptor activity(GO:0001618)
4.0	47.4	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	46.0	GO:0005096	GTPase activator activity(GO:0005096)

Showing 1 to 10 of 261 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	108.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	62.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.0	50.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	47.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.9	40.6	ST GA12 PATHWAY	G alpha 12 Pathway
0.6	40.5	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.7	31.3	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.2	30.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.4	29.0	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.4	28.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	118.9	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	67.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.9	52.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	47.2	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
2.1	42.9	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.0	42.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.5	38.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.9	35.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.9	34.7	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.9	31.4	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1

Showing 1 to 10 of 100 entries

Results for EZH2

Z-value: 1.98

Motif logo

Transcription factors associated with EZH2

Activity-expression correlation:

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: