Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for FOSB
Z-value: 0.82
Motif logo
Transcription factors associated with FOSB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg38_v1_chr19_+_45467988_45468007 | -0.14 | 4.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_31736504 Show fit | 23.50 |
ENST00000616760.1
ENST00000375784.7 ENST00000375779.6 |
chloride intracellular channel 1 |
|
| chr17_-_75154534 Show fit | 20.27 |
ENST00000356033.8
|
Jupiter microtubule associated homolog 1 |
|
| chr1_+_26280117 Show fit | 18.79 |
ENST00000319041.6
|
SH3 domain binding glutamate rich protein like 3 |
|
| chr1_+_223712491 Show fit | 18.04 |
ENST00000295006.6
|
calpain 2 |
|
| chr1_+_223701582 Show fit | 17.94 |
ENST00000433674.6
|
calpain 2 |
|
| chr1_-_23799533 Show fit | 16.05 |
ENST00000429356.5
|
UDP-galactose-4-epimerase |
|
| chrX_+_49171918 Show fit | 14.45 |
ENST00000376322.7
|
proteolipid protein 2 |
|
| chr11_-_64245816 Show fit | 13.29 |
ENST00000542235.1
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr11_-_67356970 Show fit | 12.72 |
ENST00000532830.5
|
DNA polymerase delta 4, accessory subunit |
|
| chr11_-_65900375 Show fit | 12.45 |
ENST00000312562.7
|
FOS like 1, AP-1 transcription factor subunit |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 36.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.2 | 31.7 | GO:0051225 | spindle assembly(GO:0051225) |
| 4.0 | 24.1 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.3 | 22.4 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.8 | 20.0 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.3 | 18.8 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 1.6 | 17.9 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 1.2 | 16.0 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.4 | 15.5 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 2.4 | 14.3 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 32.4 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 2.8 | 25.2 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.2 | 22.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.9 | 20.0 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.3 | 17.7 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 17.3 | GO:0005819 | spindle(GO:0005819) |
| 0.1 | 17.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 16.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 14.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 1.3 | 14.3 | GO:0005638 | lamin filament(GO:0005638) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 40.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 34.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.7 | 28.0 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.5 | 25.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.9 | 20.0 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 19.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 18.4 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 5.3 | 16.0 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 1.0 | 15.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 14.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.5 | 33.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 31.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.4 | 30.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 22.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.7 | 20.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.4 | 15.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 15.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 12.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 11.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 20.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.7 | 18.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 17.2 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.3 | 13.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.8 | 12.7 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.3 | 12.3 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.3 | 12.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.3 | 11.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 10.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 9.9 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |