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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOSL2_SMARCC1
Z-value: 1.51
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Transcription factors associated with FOSL2_SMARCC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC1 | hg38_v1_chr3_-_47781837_47781908 | 0.34 | 3.0e-07 | Click! |
| FOSL2 | hg38_v1_chr2_+_28392802_28392866 | 0.22 | 8.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL2_SMARCC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_223701582 Show fit | 94.94 |
ENST00000433674.6
|
calpain 2 |
|
| chr1_-_112704921 Show fit | 72.06 |
ENST00000414971.1
ENST00000534717.5 |
ras homolog family member C |
|
| chr6_-_31736504 Show fit | 60.35 |
ENST00000616760.1
ENST00000375784.7 ENST00000375779.6 |
chloride intracellular channel 1 |
|
| chrX_+_49171918 Show fit | 48.81 |
ENST00000376322.7
|
proteolipid protein 2 |
|
| chr11_-_64246190 Show fit | 38.42 |
ENST00000392210.6
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr11_-_64245816 Show fit | 37.81 |
ENST00000542235.1
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr1_+_156114251 Show fit | 37.77 |
ENST00000361308.9
|
lamin A/C |
|
| chr1_+_156126525 Show fit | 36.52 |
ENST00000504687.6
ENST00000473598.6 |
lamin A/C |
|
| chr1_+_156114700 Show fit | 35.27 |
ENST00000677389.1
ENST00000368300.9 ENST00000368299.7 |
lamin A/C |
|
| chrX_+_49171889 Show fit | 32.33 |
ENST00000376327.6
|
proteolipid protein 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 160.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 23.3 | 139.9 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.8 | 132.6 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 1.1 | 104.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 5.2 | 73.3 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 14.4 | 72.1 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 3.9 | 71.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.6 | 53.5 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 8.7 | 52.0 | GO:0007296 | vitellogenesis(GO:0007296) |
| 4.9 | 49.3 | GO:0002934 | desmosome organization(GO:0002934) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 243.9 | GO:0044421 | extracellular region part(GO:0044421) |
| 12.7 | 139.9 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 98.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 6.1 | 73.3 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 1.6 | 70.9 | GO:0032420 | stereocilium(GO:0032420) |
| 4.0 | 63.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.4 | 57.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.6 | 55.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 1.6 | 51.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.5 | 45.5 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 278.8 | GO:0003823 | antigen binding(GO:0003823) |
| 1.8 | 104.6 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.1 | 102.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 2.4 | 97.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.7 | 71.6 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.2 | 54.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.1 | 52.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.6 | 49.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.7 | 48.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.7 | 40.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 154.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 1.6 | 88.2 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 1.1 | 83.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 1.5 | 81.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 1.8 | 80.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 1.0 | 76.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.9 | 75.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 1.2 | 72.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 1.9 | 56.4 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 1.0 | 46.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 135.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.4 | 104.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.3 | 60.3 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 1.3 | 56.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.4 | 53.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.0 | 48.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 1.6 | 43.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 1.0 | 40.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 2.8 | 38.6 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.9 | 38.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |