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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXA1
Z-value: 1.15
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Transcription factors associated with FOXA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXA1 | hg38_v1_chr14_-_37595224_37595281 | 0.43 | 3.7e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_41528293 Show fit | 34.85 |
ENST00000455635.1
ENST00000361566.7 |
keratin 19 |
|
| chr5_+_136058849 Show fit | 29.56 |
ENST00000508076.5
|
transforming growth factor beta induced |
|
| chr18_+_3449620 Show fit | 27.92 |
ENST00000405385.7
|
TGFB induced factor homeobox 1 |
|
| chr17_-_28368012 Show fit | 22.96 |
ENST00000555059.2
|
novel protein, readthrough between VTN and SEBOX |
|
| chr19_+_18386150 Show fit | 22.44 |
ENST00000252809.3
|
growth differentiation factor 15 |
|
| chr12_-_71157872 Show fit | 16.61 |
ENST00000546561.2
|
tetraspanin 8 |
|
| chr12_-_71157992 Show fit | 16.05 |
ENST00000247829.8
|
tetraspanin 8 |
|
| chr12_-_89352395 Show fit | 15.43 |
ENST00000308385.6
|
dual specificity phosphatase 6 |
|
| chr12_-_89352487 Show fit | 14.16 |
ENST00000548755.1
ENST00000279488.8 |
dual specificity phosphatase 6 |
|
| chr12_-_52949818 Show fit | 13.42 |
ENST00000546897.5
ENST00000552551.5 |
keratin 8 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 45.9 | GO:0060706 | cell differentiation involved in embryonic placenta development(GO:0060706) |
| 0.7 | 42.0 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.2 | 31.9 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 7.4 | 29.6 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 2.4 | 26.4 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 23.1 | GO:0042493 | response to drug(GO:0042493) |
| 0.8 | 22.4 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.9 | 21.7 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 2.1 | 19.3 | GO:2000334 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 1.7 | 16.8 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 94.6 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 60.3 | GO:0009986 | cell surface(GO:0009986) |
| 0.4 | 49.2 | GO:0005604 | basement membrane(GO:0005604) |
| 7.5 | 45.0 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 40.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 25.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.3 | 24.5 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.7 | 24.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 21.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.4 | 21.2 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 45.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.4 | 36.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 31.9 | GO:0005178 | integrin binding(GO:0005178) |
| 2.0 | 29.6 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.9 | 27.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 7.9 | 23.8 | GO:0035375 | zymogen binding(GO:0035375) |
| 2.2 | 21.7 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.8 | 21.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 20.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.5 | 19.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 51.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 50.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.6 | 42.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.8 | 41.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.8 | 39.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 27.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 27.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 19.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 18.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.3 | 16.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 33.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 32.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.5 | 28.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 27.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.3 | 26.6 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.5 | 18.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 13.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 13.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.6 | 12.2 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.5 | 9.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |