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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXA2_FOXJ3
Z-value: 0.90
Motif logo
Transcription factors associated with FOXA2_FOXJ3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FOXA2
|
ENSG00000125798.15 | FOXA2 |
|
FOXJ3
|
ENSG00000198815.9 | FOXJ3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXJ3 | hg38_v1_chr1_-_42335869_42335891, hg38_v1_chr1_-_42335189_42335242 | 0.23 | 7.0e-04 | Click! |
| FOXA2 | hg38_v1_chr20_-_22584547_22584585, hg38_v1_chr20_-_22585451_22585459 | -0.15 | 2.5e-02 | Click! |
Activity profile of FOXA2_FOXJ3 motif
Sorted Z-values of FOXA2_FOXJ3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA2_FOXJ3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.2 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 3.2 | 9.7 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 2.9 | 14.5 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 2.4 | 21.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 2.2 | 6.6 | GO:0002305 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 2.0 | 6.1 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 1.9 | 7.5 | GO:0042091 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 1.7 | 5.2 | GO:0006208 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 1.6 | 4.9 | GO:0007199 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873) |
| 1.6 | 4.8 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.4 | 8.3 | GO:2000470 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 1.2 | 3.6 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 1.1 | 3.4 | GO:0045957 | regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) |
| 1.1 | 4.4 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 1.0 | 10.3 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 1.0 | 6.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.0 | 11.5 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.9 | 7.2 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.9 | 3.5 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 0.9 | 7.7 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.8 | 1.7 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 0.8 | 3.3 | GO:1903296 | regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296) |
| 0.8 | 4.9 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.8 | 3.2 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.8 | 4.7 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.8 | 3.1 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.7 | 4.5 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.7 | 3.0 | GO:1902617 | response to fluoride(GO:1902617) |
| 0.7 | 9.5 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.7 | 7.9 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.7 | 2.1 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 0.7 | 2.8 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 0.7 | 2.0 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.6 | 3.5 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.6 | 7.1 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.5 | 1.6 | GO:2000697 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 0.5 | 6.4 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.5 | 1.6 | GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference(GO:0033168) conversion of ds siRNA to ss siRNA(GO:0036404) |
| 0.5 | 1.6 | GO:0097032 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
| 0.5 | 1.5 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.5 | 2.0 | GO:0021514 | ventral spinal cord interneuron differentiation(GO:0021514) |
| 0.5 | 5.5 | GO:0015865 | purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868) |
| 0.5 | 1.9 | GO:0045763 | negative regulation of cellular amino acid metabolic process(GO:0045763) |
| 0.5 | 18.3 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.5 | 1.9 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.4 | 1.3 | GO:0000965 | mitochondrial RNA 3'-end processing(GO:0000965) miRNA catabolic process(GO:0010587) rRNA import into mitochondrion(GO:0035928) |
| 0.4 | 1.3 | GO:1903973 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 0.4 | 1.3 | GO:0046603 | negative regulation of mitotic centrosome separation(GO:0046603) |
| 0.4 | 1.2 | GO:1904692 | positive regulation of type B pancreatic cell proliferation(GO:1904692) |
| 0.4 | 1.1 | GO:0071284 | cellular response to lead ion(GO:0071284) |
| 0.4 | 0.7 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.4 | 28.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 5.9 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.3 | 3.4 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.3 | 0.7 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
| 0.3 | 4.1 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.3 | 11.5 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.3 | 10.8 | GO:0071800 | podosome assembly(GO:0071800) |
| 0.3 | 1.3 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.3 | 2.6 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.3 | 1.8 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.3 | 4.9 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.3 | 1.2 | GO:0060620 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 0.3 | 3.2 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.3 | 26.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.3 | 7.0 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.3 | 1.1 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
| 0.3 | 7.2 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.3 | 5.0 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.3 | 0.8 | GO:0008078 | mesodermal cell migration(GO:0008078) axial mesoderm morphogenesis(GO:0048319) |
| 0.2 | 0.7 | GO:0018312 | peptidyl-serine ADP-ribosylation(GO:0018312) |
| 0.2 | 2.9 | GO:0031998 | regulation of fatty acid beta-oxidation(GO:0031998) |
| 0.2 | 7.6 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.2 | 0.7 | GO:0006711 | estrogen catabolic process(GO:0006711) |
| 0.2 | 1.2 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.2 | 10.4 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.2 | 1.9 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.2 | 2.3 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.2 | 0.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.2 | 1.6 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.2 | 3.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.2 | 5.6 | GO:0097503 | sialylation(GO:0097503) |
| 0.2 | 3.7 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.2 | 1.1 | GO:0044211 | CTP salvage(GO:0044211) |
| 0.2 | 6.3 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.2 | 1.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.2 | 1.2 | GO:0035655 | interleukin-18-mediated signaling pathway(GO:0035655) |
| 0.2 | 5.0 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.2 | 4.9 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.2 | 1.6 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.2 | 0.9 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.2 | 1.4 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.2 | 1.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 2.4 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.1 | 0.4 | GO:0043606 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.1 | 1.6 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.1 | 1.5 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.1 | 1.4 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.1 | 3.8 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 12.1 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 0.5 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.1 | 0.4 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.1 | 0.8 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.1 | 0.7 | GO:0035602 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) |
| 0.1 | 1.2 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 0.1 | 1.2 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 2.5 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 1.1 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.1 | 1.4 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 0.6 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.1 | 3.9 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 1.3 | GO:0007379 | segment specification(GO:0007379) |
| 0.1 | 3.3 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
| 0.1 | 0.7 | GO:2000400 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.1 | 0.6 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.1 | 0.7 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.1 | 0.7 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 1.2 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 0.4 | GO:0015855 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823) |
| 0.1 | 1.1 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 0.8 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 1.5 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.1 | 3.7 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 0.3 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.1 | 5.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.1 | 5.0 | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) |
| 0.1 | 0.2 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.1 | 8.4 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.1 | 0.4 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 2.4 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.1 | 1.3 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.1 | 0.5 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.1 | 1.3 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.1 | 0.5 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.6 | GO:0097267 | omega-hydroxylase P450 pathway(GO:0097267) |
| 0.1 | 0.2 | GO:1903519 | apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) |
| 0.1 | 1.3 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.1 | 0.4 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.1 | 0.7 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.1 | 3.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 2.1 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 3.2 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.1 | 1.8 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.7 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 0.6 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.7 | GO:0007635 | chemosensory behavior(GO:0007635) |
| 0.1 | 2.8 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 0.8 | GO:0071168 | protein localization to chromatin(GO:0071168) |
| 0.0 | 0.3 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 3.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.2 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.0 | 0.8 | GO:0002566 | somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.0 | 0.4 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 5.0 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.0 | 0.5 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 1.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 1.3 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 3.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.5 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 0.1 | GO:0035723 | interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350) |
| 0.0 | 0.2 | GO:0030070 | insulin processing(GO:0030070) |
| 0.0 | 0.2 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 5.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.9 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 1.3 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.0 | 1.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.3 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 1.1 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.4 | GO:0016246 | RNA interference(GO:0016246) |
| 0.0 | 0.2 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.7 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 2.2 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 0.2 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.0 | 0.6 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.2 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.0 | 1.3 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.5 | GO:0045661 | regulation of myoblast differentiation(GO:0045661) |
| 0.0 | 0.3 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.0 | 0.1 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 1.2 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.0 | 0.1 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 12.2 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.2 | 3.7 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.9 | 6.3 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.8 | 10.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.8 | 7.1 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.6 | 4.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.6 | 1.9 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.6 | 1.7 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.5 | 3.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.5 | 1.6 | GO:0033167 | ARC complex(GO:0033167) |
| 0.5 | 9.5 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.5 | 10.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.5 | 1.9 | GO:0038038 | G-protein coupled receptor homodimeric complex(GO:0038038) |
| 0.4 | 3.2 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.4 | 3.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.3 | 8.5 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.3 | 5.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 1.5 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.3 | 4.9 | GO:0033177 | proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.3 | 3.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.3 | 1.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.3 | 1.1 | GO:0035363 | histone locus body(GO:0035363) |
| 0.3 | 5.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 1.0 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.2 | 7.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.2 | 3.4 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.2 | 21.8 | GO:0030315 | T-tubule(GO:0030315) |
| 0.2 | 0.9 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 1.7 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 1.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 10.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 2.4 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 0.7 | GO:0005712 | chiasma(GO:0005712) |
| 0.1 | 1.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 38.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 9.4 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 1.1 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 5.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 7.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 1.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 4.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 3.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.7 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.7 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 1.6 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 0.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 1.8 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 4.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.4 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.1 | 4.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 1.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 2.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 5.4 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 11.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 7.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 3.5 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 1.0 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 1.8 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 0.6 | GO:0070461 | SAGA-type complex(GO:0070461) |
| 0.0 | 0.9 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.2 | GO:0045281 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 1.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.2 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 4.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.5 | GO:0034358 | plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777) |
| 0.0 | 2.7 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 1.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 6.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.8 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 3.1 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.0 | 5.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 1.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 4.5 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 0.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 11.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 5.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 7.9 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 14.2 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 1.2 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.4 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 14.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 2.4 | 12.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.9 | 5.7 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
| 1.6 | 4.8 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 1.4 | 8.3 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 1.3 | 33.7 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 1.1 | 3.4 | GO:0004877 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 1.0 | 11.5 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.9 | 3.8 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.9 | 5.5 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.7 | 3.9 | GO:0070728 | leucine binding(GO:0070728) |
| 0.6 | 10.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.6 | 5.7 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.6 | 5.3 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.6 | 7.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.4 | 3.8 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.4 | 2.5 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.4 | 2.1 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.4 | 1.2 | GO:0042008 | interleukin-18 receptor activity(GO:0042008) |
| 0.4 | 1.2 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.4 | 6.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 1.2 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.4 | 5.5 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.4 | 2.9 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.4 | 3.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.4 | 10.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.4 | 11.2 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.3 | 1.4 | GO:0004982 | N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124) |
| 0.3 | 7.1 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.3 | 1.6 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.3 | 7.2 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.3 | 1.9 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.3 | 3.4 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.3 | 0.9 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.3 | 10.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.3 | 4.9 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.3 | 8.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.3 | 2.6 | GO:0043426 | MRF binding(GO:0043426) |
| 0.3 | 9.5 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.3 | 1.3 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.2 | 6.8 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 1.4 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.2 | 1.4 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.2 | 0.7 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.2 | 1.2 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.2 | 5.0 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.2 | 0.7 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.2 | 1.3 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 4.1 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 4.7 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 1.5 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.2 | 1.3 | GO:0046972 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.2 | 4.9 | GO:0046961 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.2 | 0.7 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.2 | 1.8 | GO:0005549 | odorant binding(GO:0005549) |
| 0.2 | 1.8 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.2 | 1.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 4.9 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 0.5 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.2 | 1.7 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.2 | 2.1 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.2 | 1.4 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.2 | 3.3 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.2 | 1.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.2 | 3.2 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.6 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 4.6 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 6.8 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 0.8 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 1.9 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 2.1 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.1 | 25.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.5 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.1 | 1.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 11.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 0.5 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.1 | 35.4 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 0.4 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.1 | 4.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 1.1 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 0.9 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 1.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 1.7 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 1.7 | GO:0016502 | G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 12.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 0.7 | GO:0003696 | satellite DNA binding(GO:0003696) centromeric DNA binding(GO:0019237) |
| 0.1 | 5.0 | GO:0043531 | ADP binding(GO:0043531) |
| 0.1 | 0.4 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.1 | 2.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 4.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.3 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 14.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 1.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 1.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.4 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.1 | 0.7 | GO:0015386 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.2 | GO:0070644 | vitamin D response element binding(GO:0070644) D3 vitamins binding(GO:1902271) |
| 0.1 | 0.5 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.1 | 0.7 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 1.6 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.1 | 0.3 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.1 | 1.4 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.1 | 1.1 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.2 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.1 | 0.2 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.1 | 0.4 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.1 | 1.1 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 3.1 | GO:0004520 | endodeoxyribonuclease activity(GO:0004520) |
| 0.0 | 11.6 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.7 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 1.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 1.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.8 | GO:0010181 | FMN binding(GO:0010181) |
| 0.0 | 2.9 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 4.3 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 0.2 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.0 | 2.4 | GO:0034212 | peptide N-acetyltransferase activity(GO:0034212) |
| 0.0 | 0.9 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 3.6 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 1.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.1 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 2.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 1.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.4 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 2.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.2 | GO:0005497 | androgen binding(GO:0005497) |
| 0.0 | 0.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 2.6 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.2 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.0 | 0.3 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.0 | 3.5 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.6 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 2.0 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 2.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.1 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 7.7 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 1.1 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 6.0 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.0 | 0.0 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 0.2 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 3.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.4 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.8 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.7 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 8.2 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.2 | 12.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 6.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 8.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 11.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 8.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 11.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 4.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 8.2 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 0.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 2.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 2.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 5.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 1.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.9 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 3.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.3 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 3.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.1 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 1.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 15.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 5.9 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.3 | 5.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 3.2 | REACTOME OPSINS | Genes involved in Opsins |
| 0.3 | 3.3 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.3 | 11.6 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 6.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.2 | 6.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.2 | 9.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 5.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 10.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 3.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 6.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 7.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 1.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 5.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 4.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 4.4 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.1 | 5.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 4.8 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 3.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 15.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 7.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 18.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 1.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 2.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 0.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 8.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.2 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 2.6 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.1 | 1.8 | REACTOME TCR SIGNALING | Genes involved in TCR signaling |
| 0.1 | 4.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 0.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 3.1 | REACTOME PI3K EVENTS IN ERBB4 SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.1 | 1.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 4.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 7.8 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 0.5 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.3 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.1 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.3 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.7 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 0.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.7 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 1.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 2.4 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 0.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 9.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 0.4 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |