ISMARA results: FOXA2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOXA2_FOXJ3

Z-value: 0.90

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Transcription factors associated with FOXA2_FOXJ3

Gene Symbol	Gene ID	Gene Info
FOXA2 Ensembl NCBI GeneCards UniProt	ENSG00000125798.15	FOXA2
FOXJ3 Ensembl NCBI GeneCards UniProt	ENSG00000198815.9	FOXJ3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXJ3	hg38_v1_chr1_-_42335869_42335891, hg38_v1_chr1_-_42335189_42335242	0.23	7.0e-04	Click!
FOXA2	hg38_v1_chr20_-_22584547_22584585, hg38_v1_chr20_-_22585451_22585459	-0.15	2.5e-02	Click!

Activity profile of FOXA2_FOXJ3 motif

Sorted Z-values of FOXA2_FOXJ3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA2_FOXJ3

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Promoter	Score	Transcript	Gene	Gene Info
chr2_-_2326210 Show fit	12.37	ENST00000647755.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr12_+_79045625 Show fit	12.24	ENST00000552744.5	SYT1 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 1
chr1_-_206921987 Show fit	11.85	ENST00000530505.1 ENST00000442471.4	FCMR Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgM receptor
chr16_+_6019585 Show fit	11.30	ENST00000547372.5	RBFOX1 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 1
chr6_-_122471774 Show fit	11.13	ENST00000339697.5	SERINC1 Ensembl NCBI GeneCards UniProt Show fit	serine incorporator 1
chr1_-_206921867 Show fit	10.54	ENST00000628511.2 ENST00000367091.8	FCMR Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgM receptor
chr2_-_2326378 Show fit	10.49	ENST00000647618.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr5_-_131796965 Show fit	10.43	ENST00000514667.1 ENST00000511848.1 ENST00000510461.6	ENSG00000273217.1 Ensembl NCBI GeneCards UniProt Show fit FNIP1 Ensembl NCBI GeneCards UniProt Show fit	novel protein folliculin interacting protein 1
chr16_+_56191476 Show fit	10.38	ENST00000262493.12	GNAO1 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha o1
chr1_+_50105666 Show fit	10.19	ENST00000651347.1	ELAVL4 Ensembl NCBI GeneCards UniProt Show fit	ELAV like RNA binding protein 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	28.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3	26.3	GO:0006968	cellular defense response(GO:0006968)
2.4	21.8	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.5	18.3	GO:0048665	neuron fate specification(GO:0048665)
2.9	14.5	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
4.1	12.2	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1	12.1	GO:0031338	regulation of vesicle fusion(GO:0031338)
1.0	11.5	GO:0015825	L-serine transport(GO:0015825)
0.3	11.5	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.3	10.8	GO:0071800	podosome assembly(GO:0071800)

Showing 1 to 10 of 183 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	38.9	GO:0005802	trans-Golgi network(GO:0005802)
0.2	21.8	GO:0030315	T-tubule(GO:0030315)
0.0	14.2	GO:0005694	chromosome(GO:0005694)
2.4	12.2	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1	11.7	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	11.1	GO:0000139	Golgi membrane(GO:0000139)
0.5	10.8	GO:0001891	phagocytic cup(GO:0001891)
0.1	10.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.8	10.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.5	9.5	GO:0033270	paranode region of axon(GO:0033270)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	35.4	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.3	33.7	GO:0055103	ligase regulator activity(GO:0055103)
0.1	25.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.6	14.5	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.1	14.4	GO:0017137	Rab GTPase binding(GO:0017137)
2.4	12.2	GO:0030348	syntaxin-3 binding(GO:0030348)
0.1	12.1	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1	11.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	11.6	GO:0000287	magnesium ion binding(GO:0000287)
1.0	11.5	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)

Showing 1 to 10 of 150 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	15.7	PID S1P S1P1 PATHWAY	S1P1 pathway
0.2	12.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	11.2	PID BCR 5PATHWAY	BCR signaling pathway
0.2	11.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	8.8	PID MYC PATHWAY	C-MYC pathway
0.1	8.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	8.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	8.2	PID IL12 2PATHWAY	IL12-mediated signaling events
0.2	6.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	5.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	18.8	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.7	15.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1	15.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.3	11.6	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.2	10.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.2	9.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	9.2	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	8.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	7.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	7.8	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events

Showing 1 to 10 of 61 entries

Results for FOXA2_FOXJ3

Z-value: 0.90

Motif logo

Transcription factors associated with FOXA2_FOXJ3

Activity-expression correlation:

Activity profile of FOXA2_FOXJ3 motif

Sorted Z-values of FOXA2_FOXJ3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA2_FOXJ3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: