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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXA3_FOXC2
Z-value: 0.80
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Transcription factors associated with FOXA3_FOXC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXC2 | hg38_v1_chr16_+_86566821_86566836 | -0.34 | 1.8e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXA3_FOXC2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_41528293 Show fit | 13.87 |
ENST00000455635.1
ENST00000361566.7 |
keratin 19 |
|
| chr5_+_136058849 Show fit | 12.04 |
ENST00000508076.5
|
transforming growth factor beta induced |
|
| chr18_+_3449620 Show fit | 10.82 |
ENST00000405385.7
|
TGFB induced factor homeobox 1 |
|
| chr7_+_134891566 Show fit | 9.53 |
ENST00000424922.5
ENST00000495522.1 |
caldesmon 1 |
|
| chr8_+_96584920 Show fit | 9.20 |
ENST00000521590.5
|
syndecan 2 |
|
| chr11_-_116837586 Show fit | 8.92 |
ENST00000375320.5
ENST00000359492.6 ENST00000375329.6 ENST00000375323.5 ENST00000236850.5 |
apolipoprotein A1 |
|
| chr17_-_28368012 Show fit | 8.65 |
ENST00000555059.2
|
novel protein, readthrough between VTN and SEBOX |
|
| chr7_+_112423137 Show fit | 8.56 |
ENST00000005558.8
ENST00000621379.4 |
interferon related developmental regulator 1 |
|
| chr11_+_62419025 Show fit | 8.40 |
ENST00000278282.3
|
secretoglobin family 1A member 1 |
|
| chr12_+_12891554 Show fit | 8.33 |
ENST00000014914.6
|
G protein-coupled receptor class C group 5 member A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.8 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 14.5 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.4 | 13.9 | GO:0060706 | cell differentiation involved in embryonic placenta development(GO:0060706) |
| 1.2 | 12.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 12.1 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.2 | 12.0 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
| 2.0 | 11.7 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.6 | 11.5 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.2 | 11.4 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.2 | 11.3 | GO:0001958 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 33.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.3 | 30.9 | GO:0005604 | basement membrane(GO:0005604) |
| 3.2 | 19.2 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 13.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 13.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 13.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 12.9 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.8 | 12.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 3.8 | 11.3 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 10.7 | GO:0072686 | mitotic spindle(GO:0072686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 31.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 23.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 17.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 15.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 13.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 1.7 | 12.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 11.7 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 10.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.5 | 10.4 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.1 | 10.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.4 | 21.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.3 | 20.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 19.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 19.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 12.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.3 | 12.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 12.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 12.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 10.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 13.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.5 | 12.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 11.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 11.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 11.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 10.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 10.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 10.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 9.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |