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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXC1
Z-value: 0.75
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Transcription factors associated with FOXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXC1 | hg38_v1_chr6_+_1609890_1609932 | 0.11 | 9.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_39607876 Show fit | 25.79 |
ENST00000302584.5
|
neuronal differentiation 2 |
|
| chr4_-_101346842 Show fit | 20.22 |
ENST00000507176.5
|
protein phosphatase 3 catalytic subunit alpha |
|
| chr13_-_35855627 Show fit | 14.19 |
ENST00000379893.5
|
doublecortin like kinase 1 |
|
| chr2_-_2326210 Show fit | 12.71 |
ENST00000647755.1
|
myelin transcription factor 1 like |
|
| chr16_+_7303245 Show fit | 12.47 |
ENST00000674626.1
|
RNA binding fox-1 homolog 1 |
|
| chr19_-_36032799 Show fit | 11.37 |
ENST00000592017.5
ENST00000360535.9 |
CAP-Gly domain containing linker protein 3 |
|
| chr2_-_2326378 Show fit | 10.67 |
ENST00000647618.1
|
myelin transcription factor 1 like |
|
| chr16_+_6019585 Show fit | 10.58 |
ENST00000547372.5
|
RNA binding fox-1 homolog 1 |
|
| chr4_-_101347327 Show fit | 10.52 |
ENST00000394853.8
|
protein phosphatase 3 catalytic subunit alpha |
|
| chr1_+_204870831 Show fit | 9.76 |
ENST00000404076.5
ENST00000539706.6 |
neurofascin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.4 | 49.7 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.5 | 39.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 6.4 | 25.8 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.5 | 24.8 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.1 | 21.9 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.5 | 21.2 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.2 | 19.1 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 1.2 | 16.1 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 5.0 | 15.1 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 1.3 | 13.4 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 49.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 40.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 31.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.6 | 26.0 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 22.5 | GO:0045202 | synapse(GO:0045202) |
| 0.9 | 16.1 | GO:0033270 | paranode region of axon(GO:0033270) |
| 1.7 | 15.1 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.2 | 15.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 1.0 | 13.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 2.0 | 9.8 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 49.7 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.2 | 47.2 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.5 | 32.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 23.1 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.1 | 22.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 19.3 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.5 | 16.1 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.6 | 15.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.8 | 13.4 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.4 | 13.4 | GO:0005521 | lamin binding(GO:0005521) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 49.8 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 16.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 15.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 10.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 6.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 6.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 5.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 5.2 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 4.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 49.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.7 | 19.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.4 | 16.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 13.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 11.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 9.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 8.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 7.5 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 6.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 5.2 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |