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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 1.31
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Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000251493.5 | FOXD1 | |
| ENSG00000150907.10 | FOXO1 | |
| ENSG00000204060.7 | FOXO6 | |
| ENSG00000176165.12 | FOXG1 | |
| ENSG00000114861.23 | FOXP1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO1 | hg38_v1_chr13_-_40666600_40666650 | 0.59 | 3.1e-22 | Click! |
| FOXD1 | hg38_v1_chr5_-_73448769_73448784 | -0.36 | 5.7e-08 | Click! |
| FOXG1 | hg38_v1_chr14_+_28766755_28766802 | -0.05 | 5.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_145996567 Show fit | 60.68 |
ENST00000582401.6
|
thioredoxin interacting protein |
|
| chr12_-_92145838 Show fit | 49.35 |
ENST00000256015.5
|
BTG anti-proliferation factor 1 |
|
| chrX_-_107717054 Show fit | 41.74 |
ENST00000503515.1
ENST00000372397.6 |
TSC22 domain family member 3 |
|
| chr11_+_117178886 Show fit | 40.41 |
ENST00000620360.4
|
SID1 transmembrane family member 2 |
|
| chr3_-_18424533 Show fit | 35.95 |
ENST00000417717.6
|
SATB homeobox 1 |
|
| chr11_+_117179127 Show fit | 34.13 |
ENST00000278951.11
|
SID1 transmembrane family member 2 |
|
| chr11_+_117178728 Show fit | 33.43 |
ENST00000532960.5
ENST00000324225.9 |
SID1 transmembrane family member 2 |
|
| chr13_-_46142834 Show fit | 33.26 |
ENST00000674665.1
|
lymphocyte cytosolic protein 1 |
|
| chr6_+_89081787 Show fit | 32.61 |
ENST00000354922.3
|
proline rich nuclear receptor coactivator 1 |
|
| chr19_+_12791470 Show fit | 32.55 |
ENST00000302754.6
|
JunB proto-oncogene, AP-1 transcription factor subunit |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 112.1 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.4 | 109.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.9 | 57.1 | GO:0002347 | response to tumor cell(GO:0002347) |
| 4.3 | 55.4 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.6 | 48.5 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 6.6 | 46.2 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 5.4 | 42.9 | GO:0070236 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 1.0 | 42.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 3.1 | 40.0 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 1.9 | 39.0 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 138.8 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.5 | 103.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 53.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.6 | 50.7 | GO:0005776 | autophagosome(GO:0005776) |
| 1.2 | 40.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 1.5 | 39.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 4.8 | 38.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.9 | 37.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 7.2 | 35.9 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.1 | 31.3 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 121.1 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 18.7 | 112.1 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.2 | 63.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 57.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.3 | 53.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 3.3 | 46.2 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 4.6 | 41.7 | GO:0043426 | MRF binding(GO:0043426) |
| 1.0 | 35.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 35.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 8.1 | 32.2 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 129.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.9 | 50.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 41.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 40.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.9 | 33.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 32.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 1.1 | 26.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.6 | 25.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 25.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 21.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 119.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 3.8 | 69.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 62.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.9 | 45.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.9 | 38.5 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.8 | 31.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 30.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.1 | 26.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.9 | 26.2 | REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK |
| 0.5 | 21.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |