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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXD3_FOXI1_FOXF1
Z-value: 1.01
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Transcription factors associated with FOXD3_FOXI1_FOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXI1 | hg38_v1_chr5_+_170105892_170105913 | 0.21 | 2.0e-03 | Click! |
| FOXF1 | hg38_v1_chr16_+_86510507_86510539 | 0.18 | 6.8e-03 | Click! |
| FOXD3 | hg38_v1_chr1_+_63322558_63322583 | 0.06 | 3.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD3_FOXI1_FOXF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111910888 Show fit | 24.69 |
ENST00000525823.1
ENST00000528961.6 |
crystallin alpha B |
|
| chr11_-_111910790 Show fit | 23.57 |
ENST00000533280.6
|
crystallin alpha B |
|
| chr2_+_172860038 Show fit | 19.41 |
ENST00000538974.5
ENST00000540783.5 |
Rap guanine nucleotide exchange factor 4 |
|
| chr11_-_111910830 Show fit | 19.26 |
ENST00000526167.5
ENST00000651650.1 |
crystallin alpha B |
|
| chr3_-_195583931 Show fit | 17.70 |
ENST00000343267.8
ENST00000421243.5 ENST00000453131.1 |
apolipoprotein D |
|
| chr1_+_50105666 Show fit | 16.66 |
ENST00000651347.1
|
ELAV like RNA binding protein 4 |
|
| chr5_+_174045673 Show fit | 15.98 |
ENST00000303177.8
ENST00000519867.5 |
neuronal vesicle trafficking associated 2 |
|
| chr4_-_152382522 Show fit | 15.79 |
ENST00000296555.11
|
F-box and WD repeat domain containing 7 |
|
| chr5_-_88883701 Show fit | 14.31 |
ENST00000636998.1
|
myocyte enhancer factor 2C |
|
| chr4_+_70721953 Show fit | 14.20 |
ENST00000381006.8
ENST00000226328.8 |
RUN and FYVE domain containing 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 66.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.5 | 38.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 29.5 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 3.1 | 24.8 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 3.0 | 24.0 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 23.8 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 1.6 | 20.9 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 1.6 | 19.6 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 3.3 | 19.5 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 5.9 | 17.7 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 69.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.2 | 67.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 35.7 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 32.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.6 | 32.3 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.2 | 31.2 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.1 | 29.0 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.6 | 25.9 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 25.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.7 | 19.0 | GO:0005955 | calcineurin complex(GO:0005955) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 67.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 37.1 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.6 | 28.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.3 | 27.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.8 | 27.7 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 1.5 | 25.8 | GO:0003680 | AT DNA binding(GO:0003680) |
| 1.2 | 25.8 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.5 | 24.8 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.7 | 24.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.5 | 22.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 45.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 26.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.3 | 25.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 19.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 15.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 14.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 13.8 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 12.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.4 | 12.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 11.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 49.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.8 | 31.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.6 | 24.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 16.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 16.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.6 | 14.5 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.7 | 13.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 12.8 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.3 | 12.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.5 | 10.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |