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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXF2_FOXJ1
Z-value: 0.74
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Transcription factors associated with FOXF2_FOXJ1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXJ1 | hg38_v1_chr17_-_76141240_76141267 | 0.35 | 1.7e-07 | Click! |
| FOXF2 | hg38_v1_chr6_+_1389553_1389605 | 0.12 | 7.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXF2_FOXJ1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 43.3 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 3.6 | 25.1 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.1 | 22.8 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.1 | 20.9 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.2 | 18.4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 2.1 | 17.1 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.7 | 12.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 3.0 | 11.9 | GO:0060620 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 2.3 | 11.5 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.1 | 10.1 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 53.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 29.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 29.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 18.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.9 | 17.1 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 16.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 12.4 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.7 | 11.9 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 1.4 | 11.4 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 10.3 | GO:0005815 | microtubule organizing center(GO:0005815) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 25.1 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 21.3 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 1.4 | 17.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 17.0 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 2.4 | 11.9 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 2.9 | 11.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 11.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 10.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.6 | 8.8 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 2.1 | 8.3 | GO:0097001 | ceramide binding(GO:0097001) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 48.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 8.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 8.2 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 7.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 5.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 5.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.1 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.2 | 3.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.6 | 13.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 13.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 8.8 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 8.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 7.2 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 6.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 6.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 5.6 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 5.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |