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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOXJ2

Z-value: 0.72

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Transcription factors associated with FOXJ2

Gene Symbol Gene ID Gene Info
FOXJ2
ENSG00000065970.9 FOXJ2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXJ2hg38_v1_chr12_+_8032692_8032744-0.282.9e-05Click!

Activity profile of FOXJ2 motif

Sorted Z-values of FOXJ2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXJ2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_197146620 17.36 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr1_-_197146688 17.07 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr18_+_3447562 13.55 ENST00000618001.4
TGIF1
TGFB induced factor homeobox 1
chr3_+_172039556 13.28 ENST00000415807.7
ENST00000421757.5
FNDC3B
fibronectin type III domain containing 3B
chr11_+_35180279 12.69 ENST00000531873.5
CD44
CD44 molecule (Indian blood group)
chr1_+_44746401 12.34 ENST00000372217.5
KIF2C
kinesin family member 2C
chr15_+_66505289 12.19 ENST00000565627.5
ENST00000564179.5
ENST00000307897.10
ZWILCH
zwilch kinetochore protein
chr15_+_66504959 12.02 ENST00000535141.6
ENST00000613446.4
ENST00000446801.6
ZWILCH
zwilch kinetochore protein
chr11_+_35180342 11.98 ENST00000639002.1
CD44
CD44 molecule (Indian blood group)
chr15_+_64136330 11.03 ENST00000560861.1
SNX1
sorting nexin 1
chr2_-_224569782 10.27 ENST00000409096.5
CUL3
cullin 3
chr16_+_3018390 10.03 ENST00000573001.5
TNFRSF12A
TNF receptor superfamily member 12A
chr9_+_5890872 9.04 ENST00000381477.8
ENST00000381476.5
ENST00000381471.1
MLANA
melan-A
chr9_+_107284053 8.70 ENST00000416373.6
RAD23B
RAD23 homolog B, nucleotide excision repair protein
chr8_-_80080816 8.09 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
TPD52
tumor protein D52
chr1_-_179877790 7.27 ENST00000495650.1
ENST00000367612.7
ENST00000482587.5
ENST00000609928.6
TOR1AIP2
torsin 1A interacting protein 2
chr13_-_36999295 7.15 ENST00000679673.1
ENST00000679572.1
ENST00000239891.4
ENST00000681763.1
ENST00000680671.1
ENST00000680012.1
ENST00000679837.1
ENST00000443765.6
ALG5
ALG5 dolichyl-phosphate beta-glucosyltransferase
chr6_+_10747765 6.91 ENST00000461342.5
ENST00000475942.5
ENST00000379542.10
ENST00000379530.7
ENST00000473276.5
ENST00000481240.5
ENST00000467317.5
TMEM14B
transmembrane protein 14B
chr6_+_10747753 6.81 ENST00000612333.4
TMEM14B
transmembrane protein 14B
chr7_+_77840122 6.69 ENST00000450574.5
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr3_+_157436842 6.64 ENST00000295927.4
PTX3
pentraxin 3
chr7_-_101211672 6.50 ENST00000454310.5
PLOD3
procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
chr20_+_57351528 6.47 ENST00000395840.6
RAE1
ribonucleic acid export 1
chr2_+_231056845 6.32 ENST00000677230.1
ENST00000677259.1
ENST00000677180.1
ENST00000409643.6
ENST00000619128.5
ENST00000678679.1
ENST00000676740.1
ENST00000308696.11
ENST00000440838.5
ENST00000373635.9
PSMD1
proteasome 26S subunit, non-ATPase 1
chr8_+_30387064 6.18 ENST00000523115.5
ENST00000519647.5
RBPMS
RNA binding protein, mRNA processing factor
chr6_-_170553216 5.76 ENST00000262193.7
PSMB1
proteasome 20S subunit beta 1
chr15_-_55196608 5.43 ENST00000677989.1
ENST00000562895.2
ENST00000569386.2
RSL24D1
ribosomal L24 domain containing 1
chr1_+_95151377 5.40 ENST00000604203.1
TLCD4-RWDD3
TLCD4-RWDD3 readthrough
chr12_-_53676720 5.21 ENST00000673498.1
ATP5MC2
ATP synthase membrane subunit c locus 2
chr12_-_53677397 5.08 ENST00000338662.6
ENST00000552242.5
ATP5MC2
ATP synthase membrane subunit c locus 2
chr2_-_85414039 5.05 ENST00000447219.6
ENST00000409670.5
ENST00000409724.5
CAPG
capping actin protein, gelsolin like
chr13_-_37598750 4.96 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
POSTN
periostin
chr20_+_37744630 4.88 ENST00000373473.5
CTNNBL1
catenin beta like 1
chr21_-_34526850 4.57 ENST00000481448.5
ENST00000381132.6
RCAN1
regulator of calcineurin 1
chr17_+_68515399 4.56 ENST00000588188.6
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr11_-_82845734 4.49 ENST00000681883.1
ENST00000680040.1
ENST00000681432.1
PRCP
prolylcarboxypeptidase
chr4_+_87975829 4.33 ENST00000614857.5
SPP1
secreted phosphoprotein 1
chr10_+_103245887 4.30 ENST00000441178.2
RPEL1
ribulose-5-phosphate-3-epimerase like 1
chr1_-_44986568 4.30 ENST00000372183.7
ENST00000360403.7
ENST00000620860.4
EIF2B3
eukaryotic translation initiation factor 2B subunit gamma
chr1_-_93614091 4.26 ENST00000370247.7
BCAR3
BCAR3 adaptor protein, NSP family member
chr16_-_30429207 4.25 ENST00000568434.1
DCTPP1
dCTP pyrophosphatase 1
chr12_+_57229694 4.19 ENST00000557487.5
ENST00000328923.8
ENST00000555634.5
ENST00000556689.5
SHMT2
serine hydroxymethyltransferase 2
chr3_+_51983438 4.16 ENST00000476351.5
ENST00000476854.5
ENST00000494103.5
ENST00000404366.7
ENST00000635797.1
ENST00000636358.2
ENST00000469863.1
ACY1
aminoacylase 1
chr12_-_8662619 4.00 ENST00000544889.1
ENST00000543369.5
MFAP5
microfibril associated protein 5
chr15_-_66504832 3.99 ENST00000569438.2
ENST00000569696.5
ENST00000307961.11
RPL4
ribosomal protein L4
chr15_-_56465130 3.87 ENST00000260453.4
MNS1
meiosis specific nuclear structural 1
chr11_-_82846128 3.84 ENST00000679809.1
ENST00000680186.1
ENST00000681592.1
PRCP
prolylcarboxypeptidase
chr19_+_926001 3.82 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr11_+_57805541 3.72 ENST00000683201.1
ENST00000683769.1
CTNND1
catenin delta 1
chr6_+_31494881 3.63 ENST00000538442.5
MICB
MHC class I polypeptide-related sequence B
chr12_-_8662703 3.56 ENST00000535336.5
MFAP5
microfibril associated protein 5
chrX_-_53422170 3.52 ENST00000675504.1
SMC1A
structural maintenance of chromosomes 1A
chr12_+_27710795 3.51 ENST00000081029.8
ENST00000538315.5
ENST00000542791.1
MRPS35
mitochondrial ribosomal protein S35
chr4_+_173370908 3.51 ENST00000296504.4
SAP30
Sin3A associated protein 30
chr6_-_99394164 3.50 ENST00000254759.8
COQ3
coenzyme Q3, methyltransferase
chr3_+_179148341 3.44 ENST00000263967.4
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr3_+_128726151 3.36 ENST00000675342.1
ENST00000493186.6
ENST00000674748.1
ENST00000265062.8
ENST00000482525.5
RAB7A
RAB7A, member RAS oncogene family
chr1_+_93079234 3.24 ENST00000540243.5
ENST00000545708.5
MTF2
metal response element binding transcription factor 2
chr21_-_34526815 3.17 ENST00000492600.1
RCAN1
regulator of calcineurin 1
chr3_+_128726130 3.08 ENST00000676425.1
ENST00000675864.1
RAB7A
RAB7A, member RAS oncogene family
chr1_-_43389768 2.89 ENST00000372455.4
ENST00000372457.9
ENST00000290663.10
MED8
mediator complex subunit 8
chr17_-_58417521 2.83 ENST00000584437.5
ENST00000407977.7
RNF43
ring finger protein 43
chr15_+_42404866 2.78 ENST00000674041.1
ENST00000565559.5
ENST00000673750.1
ENST00000674135.1
CAPN3
calpain 3
chr17_+_59209867 2.77 ENST00000578922.1
ENST00000300917.10
SMG8
SMG8 nonsense mediated mRNA decay factor
chr15_+_67138001 2.76 ENST00000439724.7
SMAD3
SMAD family member 3
chr6_+_30571393 2.75 ENST00000376545.7
ENST00000441867.6
ENST00000468958.1
ENST00000326195.13
ABCF1
ATP binding cassette subfamily F member 1
chr21_-_26051023 2.71 ENST00000415997.1
APP
amyloid beta precursor protein
chr4_+_26343156 2.59 ENST00000680928.1
ENST00000681260.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr9_+_130693756 2.55 ENST00000546165.5
ENST00000372352.7
ENST00000372358.10
ENST00000372351.7
ENST00000372350.7
ENST00000495699.2
EXOSC2
exosome component 2
chr19_+_54115726 2.51 ENST00000445811.5
ENST00000321030.9
ENST00000445124.5
ENST00000447810.5
PRPF31
pre-mRNA processing factor 31
chr17_-_58417547 2.48 ENST00000577716.5
RNF43
ring finger protein 43
chr7_-_32490361 2.45 ENST00000410044.5
ENST00000450169.7
ENST00000409987.5
ENST00000409782.5
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr6_-_24666591 2.44 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr8_+_47960883 2.41 ENST00000648407.1
ENST00000649838.1
ENST00000649919.1
ENST00000262105.6
ENST00000649973.1
MCM4
minichromosome maintenance complex component 4
chr1_-_217076889 2.39 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chr14_-_24084625 2.35 ENST00000397002.6
NRL
neural retina leucine zipper
chr15_+_42404820 2.31 ENST00000673839.1
ENST00000673978.1
CAPN3
calpain 3
chr3_-_57199938 2.11 ENST00000473921.2
ENST00000295934.8
HESX1
HESX homeobox 1
chr9_-_26892732 2.09 ENST00000333916.8
ENST00000520187.1
CAAP1
caspase activity and apoptosis inhibitor 1
chr8_+_100158029 2.06 ENST00000251809.4
SPAG1
sperm associated antigen 1
chrX_+_100644183 2.05 ENST00000640889.1
ENST00000373004.5
SRPX2
sushi repeat containing protein X-linked 2
chr19_+_13023958 2.01 ENST00000587760.5
ENST00000585575.5
NFIX
nuclear factor I X
chr21_-_36079382 1.93 ENST00000399201.5
SETD4
SET domain containing 4
chr16_-_18896874 1.66 ENST00000565324.5
ENST00000561947.5
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr1_-_152325232 1.60 ENST00000368799.2
FLG
filaggrin
chr8_-_115668966 1.52 ENST00000395715.8
TRPS1
transcriptional repressor GATA binding 1
chr4_-_139084289 1.51 ENST00000510408.5
ENST00000379549.7
ENST00000358635.7
ELF2
E74 like ETS transcription factor 2
chr10_+_116621306 1.42 ENST00000611850.4
ENST00000591655.3
PNLIPRP2
pancreatic lipase related protein 2 (gene/pseudogene)
chr1_-_240612147 1.37 ENST00000318160.5
GREM2
gremlin 2, DAN family BMP antagonist
chr12_-_8662808 1.33 ENST00000359478.7
ENST00000396549.6
MFAP5
microfibril associated protein 5
chr1_+_224183197 1.27 ENST00000323699.9
DEGS1
delta 4-desaturase, sphingolipid 1
chr8_+_47961028 1.25 ENST00000650216.1
MCM4
minichromosome maintenance complex component 4
chr6_-_56642788 1.25 ENST00000439203.5
ENST00000518935.5
ENST00000370765.11
ENST00000244364.10
DST
dystonin
chr2_-_55010348 1.25 ENST00000394609.6
RTN4
reticulon 4
chr6_-_26123910 1.24 ENST00000314332.5
ENST00000396984.1
H2BC4
H2B clustered histone 4
chr19_+_11547840 1.23 ENST00000588935.1
CNN1
calponin 1
chrX_+_109535775 1.22 ENST00000218004.5
NXT2
nuclear transport factor 2 like export factor 2
chr15_+_42404842 1.20 ENST00000673928.1
CAPN3
calpain 3
chr3_+_122384167 1.12 ENST00000232125.9
ENST00000477892.5
ENST00000469967.1
FAM162A
family with sequence similarity 162 member A
chr12_-_52680398 1.09 ENST00000252244.3
KRT1
keratin 1
chr15_+_42404793 1.05 ENST00000561817.5
ENST00000674018.1
ENST00000397204.9
ENST00000673886.1
ENST00000674139.1
ENST00000673851.1
CAPN3
calpain 3
chr12_-_68159732 0.95 ENST00000229135.4
IFNG
interferon gamma
chr4_-_163613505 0.93 ENST00000339875.9
MARCHF1
membrane associated ring-CH-type finger 1
chr12_-_102480604 0.89 ENST00000392905.7
IGF1
insulin like growth factor 1
chr2_-_65366650 0.85 ENST00000443619.6
SPRED2
sprouty related EVH1 domain containing 2
chr1_+_28553075 0.81 ENST00000373830.4
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
chr17_+_39461468 0.75 ENST00000447079.6
ENST00000584632.5
CDK12
cyclin dependent kinase 12
chr12_-_8662881 0.74 ENST00000433590.6
MFAP5
microfibril associated protein 5
chr9_+_5510492 0.73 ENST00000397747.5
PDCD1LG2
programmed cell death 1 ligand 2
chr20_+_34194569 0.73 ENST00000568305.5
ASIP
agouti signaling protein
chr6_-_43053832 0.71 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr4_-_122621011 0.71 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chr12_-_120325936 0.59 ENST00000549767.1
PLA2G1B
phospholipase A2 group IB
chr9_-_21141832 0.59 ENST00000380229.4
IFNW1
interferon omega 1
chr10_+_116545907 0.59 ENST00000369221.2
PNLIP
pancreatic lipase
chr4_+_67558719 0.54 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr6_+_151809105 0.54 ENST00000427531.6
ESR1
estrogen receptor 1
chrX_-_108439472 0.52 ENST00000372216.8
COL4A6
collagen type IV alpha 6 chain
chr12_-_10098940 0.49 ENST00000420265.2
CLEC1A
C-type lectin domain family 1 member A
chr17_-_66229380 0.47 ENST00000205948.11
APOH
apolipoprotein H
chr7_+_73827737 0.43 ENST00000435050.1
CLDN4
claudin 4
chr6_-_31592992 0.38 ENST00000340027.10
NCR3
natural cytotoxicity triggering receptor 3
chr6_-_31592952 0.34 ENST00000376073.8
ENST00000376072.7
NCR3
natural cytotoxicity triggering receptor 3
chr2_+_156473569 0.34 ENST00000409674.5
ENST00000409125.8
GPD2
glycerol-3-phosphate dehydrogenase 2
chr10_+_8054808 0.33 ENST00000346208.4
GATA3
GATA binding protein 3
chr1_-_27374816 0.32 ENST00000270879.9
ENST00000354982.2
FCN3
ficolin 3
chr3_-_149221811 0.30 ENST00000455472.3
ENST00000264613.11
CP
ceruloplasmin
chrX_+_108439866 0.25 ENST00000361603.7
COL4A5
collagen type IV alpha 5 chain
chr11_-_66546021 0.17 ENST00000310442.5
ZDHHC24
zinc finger DHHC-type containing 24
chr12_-_102480552 0.17 ENST00000337514.11
ENST00000307046.8
IGF1
insulin like growth factor 1
chr4_+_88378842 0.12 ENST00000264346.12
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr1_+_162632454 0.09 ENST00000367921.8
ENST00000367922.7
DDR2
discoidin domain receptor tyrosine kinase 2
chr12_-_102480638 0.03 ENST00000392904.5
IGF1
insulin like growth factor 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 34.4 GO:0009786 regulation of asymmetric cell division(GO:0009786)
3.4 10.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
2.2 6.6 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
2.1 6.4 GO:0007174 epidermal growth factor catabolic process(GO:0007174)
1.9 24.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.8 5.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
1.6 6.5 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.4 4.3 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
1.4 12.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.3 7.6 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
1.1 5.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
1.0 8.3 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
1.0 5.0 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.9 4.3 GO:0019323 pentose catabolic process(GO:0019323)
0.9 3.4 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.8 4.2 GO:0009213 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.8 2.5 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.8 7.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.8 3.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.8 11.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.7 3.5 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.7 4.2 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.6 7.3 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.5 6.5 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.5 4.3 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.5 2.3 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.5 2.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.5 3.6 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.5 2.7 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874)
0.4 2.5 GO:0048254 snoRNA localization(GO:0048254)
0.4 2.6 GO:1901189 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.4 6.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.4 0.7 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.4 1.4 GO:0019376 galactolipid catabolic process(GO:0019376)
0.3 1.4 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.3 1.0 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.3 4.6 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.3 3.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 3.9 GO:0070986 left/right axis specification(GO:0070986)
0.2 8.7 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.2 9.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 1.1 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.2 3.5 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.2 3.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 0.5 GO:1903973 negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.2 7.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 4.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 2.0 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 3.7 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.2 1.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 24.2 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 0.6 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.1 2.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 12.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 3.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 1.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 1.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.7 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.1 7.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.5 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 3.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 2.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.7 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 1.2 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 0.8 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.3 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.1 0.5 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 2.5 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 4.9 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.1 1.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 0.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 3.8 GO:1902400 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.0 6.3 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 3.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.7 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.6 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 4.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.1 GO:1901536 pro-T cell differentiation(GO:0002572) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) regulation of cellular response to X-ray(GO:2000683)
0.0 1.1 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 1.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.7 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 2.4 GO:0006302 double-strand break repair(GO:0006302)
0.0 0.7 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 24.2 GO:1990423 RZZ complex(GO:1990423)
3.8 34.4 GO:0036449 microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687)
2.2 24.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
2.2 8.7 GO:0071942 XPC complex(GO:0071942)
2.1 6.4 GO:0032419 extrinsic component of lysosome membrane(GO:0032419)
2.1 6.3 GO:0034515 proteasome storage granule(GO:0034515)
1.6 11.0 GO:0030905 retromer, tubulation complex(GO:0030905)
1.3 10.3 GO:0005827 polar microtubule(GO:0005827)
0.7 3.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.6 2.5 GO:0005687 U4 snRNP(GO:0005687)
0.5 4.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.5 3.5 GO:0030893 meiotic cohesin complex(GO:0030893)
0.5 9.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.5 4.2 GO:0070552 BRISC complex(GO:0070552)
0.5 6.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.5 11.9 GO:0035371 microtubule plus-end(GO:0035371)
0.4 5.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.4 5.8 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.4 2.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.3 2.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 2.7 GO:1990761 growth cone lamellipodium(GO:1990761)
0.3 2.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 3.7 GO:0005915 zonula adherens(GO:0005915)
0.3 3.7 GO:0042555 MCM complex(GO:0042555)
0.2 6.2 GO:0005685 U1 snRNP(GO:0005685)
0.2 4.9 GO:0000974 Prp19 complex(GO:0000974)
0.2 4.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 6.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 2.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 0.7 GO:1990393 3M complex(GO:1990393)
0.1 3.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 3.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 8.8 GO:0045178 basal part of cell(GO:0045178)
0.1 0.8 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 6.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 2.9 GO:0016592 mediator complex(GO:0016592)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 6.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.7 GO:0001533 cornified envelope(GO:0001533)
0.1 0.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 9.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 3.9 GO:0036126 sperm flagellum(GO:0036126)
0.0 3.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 2.4 GO:0016605 PML body(GO:0016605)
0.0 4.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.3 GO:0031208 POZ domain binding(GO:0031208)
2.2 11.0 GO:1990460 leptin receptor binding(GO:1990460)
1.6 6.5 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
1.5 12.3 GO:0019237 centromeric DNA binding(GO:0019237)
1.4 4.3 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
1.2 6.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
1.2 3.5 GO:0008169 C-methyltransferase activity(GO:0008169)
0.9 6.6 GO:0001849 complement component C1q binding(GO:0001849)
0.9 7.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.8 2.4 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.7 7.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.7 4.2 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.7 4.2 GO:0004046 aminoacylase activity(GO:0004046)
0.7 24.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.6 2.5 GO:0030622 U4atac snRNA binding(GO:0030622)
0.6 3.5 GO:0036033 mediator complex binding(GO:0036033)
0.5 16.3 GO:0070410 co-SMAD binding(GO:0070410)
0.4 7.3 GO:0031432 titin binding(GO:0031432)
0.4 3.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 8.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.4 4.2 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.3 3.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 2.7 GO:0051425 PTB domain binding(GO:0051425)
0.3 2.5 GO:0008312 7S RNA binding(GO:0008312)
0.2 4.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 2.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 7.3 GO:0001671 ATPase activator activity(GO:0001671)
0.2 5.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 2.6 GO:0000150 recombinase activity(GO:0000150)
0.1 2.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.7 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 5.3 GO:0005109 frizzled binding(GO:0005109)
0.1 8.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 0.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 1.4 GO:0036122 BMP binding(GO:0036122)
0.1 10.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 31.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.3 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.1 6.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 6.5 GO:0043130 ubiquitin binding(GO:0043130)
0.1 3.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 3.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 4.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 2.8 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 9.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 4.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 5.0 GO:0008201 heparin binding(GO:0008201)
0.0 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.9 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 2.9 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 10.0 GO:0045296 cadherin binding(GO:0045296)
0.0 3.2 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.3 GO:0009055 electron carrier activity(GO:0009055)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 24.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 17.3 PID AURORA B PATHWAY Aurora B signaling
0.2 21.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 3.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 10.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 9.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 4.3 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 17.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.5 PID ATM PATHWAY ATM pathway
0.1 2.4 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 4.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 5.3 PID P73PATHWAY p73 transcription factor network
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID IGF1 PATHWAY IGF1 pathway
0.0 6.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 6.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.0 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 24.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 7.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.4 12.3 REACTOME KINESINS Genes involved in Kinesins
0.3 8.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 16.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 8.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.3 6.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3 27.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 2.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2 12.1 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.2 2.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 2.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 4.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 3.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 7.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 8.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 3.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 11.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.3 REACTOME TRANSLATION Genes involved in Translation
0.0 1.0 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 4.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.0 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.0 5.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling