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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXJ2
Z-value: 0.72
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Transcription factors associated with FOXJ2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXJ2 | hg38_v1_chr12_+_8032692_8032744 | -0.28 | 2.9e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXJ2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_197146620 Show fit | 17.36 |
ENST00000367409.9
ENST00000680265.1 |
assembly factor for spindle microtubules |
|
| chr1_-_197146688 Show fit | 17.07 |
ENST00000294732.11
|
assembly factor for spindle microtubules |
|
| chr18_+_3447562 Show fit | 13.55 |
ENST00000618001.4
|
TGFB induced factor homeobox 1 |
|
| chr3_+_172039556 Show fit | 13.28 |
ENST00000415807.7
ENST00000421757.5 |
fibronectin type III domain containing 3B |
|
| chr11_+_35180279 Show fit | 12.69 |
ENST00000531873.5
|
CD44 molecule (Indian blood group) |
|
| chr1_+_44746401 Show fit | 12.34 |
ENST00000372217.5
|
kinesin family member 2C |
|
| chr15_+_66505289 Show fit | 12.19 |
ENST00000565627.5
ENST00000564179.5 ENST00000307897.10 |
zwilch kinetochore protein |
|
| chr15_+_66504959 Show fit | 12.02 |
ENST00000535141.6
ENST00000613446.4 ENST00000446801.6 |
zwilch kinetochore protein |
|
| chr11_+_35180342 Show fit | 11.98 |
ENST00000639002.1
|
CD44 molecule (Indian blood group) |
|
| chr15_+_64136330 Show fit | 11.03 |
ENST00000560861.1
|
sorting nexin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.5 | 34.4 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 1.9 | 24.7 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 24.2 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 1.4 | 12.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 12.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.8 | 11.0 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 3.4 | 10.3 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.2 | 9.6 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.2 | 8.7 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 1.0 | 8.3 | GO:0002254 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 34.4 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 2.2 | 24.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 6.1 | 24.2 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.5 | 11.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 1.6 | 11.0 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 1.3 | 10.3 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.5 | 9.6 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 9.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 8.8 | GO:0045178 | basal part of cell(GO:0045178) |
| 2.2 | 8.7 | GO:0071942 | XPC complex(GO:0071942) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.7 | 24.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.5 | 16.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 1.5 | 12.3 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 2.2 | 11.0 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 3.4 | 10.3 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.1 | 10.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 10.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 9.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 8.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 24.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 21.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 17.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 17.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 10.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 9.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 6.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 6.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.3 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 24.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 16.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.4 | 12.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 12.1 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 11.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 8.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.3 | 8.3 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 8.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 7.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |