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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 1.69
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXK1 | hg38_v1_chr7_+_4682252_4682314 | 0.65 | 2.2e-27 | Click! |
| FOXP3 | hg38_v1_chrX_-_49264668_49264800 | 0.45 | 2.0e-12 | Click! |
| FOXB1 | hg38_v1_chr15_+_60004305_60004319 | 0.24 | 3.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.7 | 215.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 8.5 | 144.4 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 9.7 | 125.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 9.8 | 78.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 25.6 | 76.7 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.5 | 75.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 14.4 | 72.0 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 5.7 | 68.8 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 9.7 | 67.7 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.7 | 66.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 277.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 13.5 | 215.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.7 | 152.9 | GO:0030426 | growth cone(GO:0030426) |
| 9.7 | 125.7 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 6.1 | 123.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.5 | 104.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.0 | 103.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 92.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 5.8 | 87.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 76.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 277.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 7.1 | 214.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 6.8 | 143.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 6.9 | 82.2 | GO:0008430 | selenium binding(GO:0008430) |
| 0.5 | 79.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 2.7 | 74.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 18.0 | 72.0 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 23.5 | 70.5 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 4.8 | 67.7 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 1.0 | 64.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 244.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 141.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 140.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 2.2 | 114.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.6 | 106.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 85.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.8 | 53.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.8 | 38.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.5 | 28.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.5 | 26.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 131.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 4.3 | 116.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.9 | 106.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 4.5 | 97.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.6 | 81.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 3.3 | 79.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 1.5 | 68.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.7 | 60.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.7 | 54.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 3.2 | 50.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |