ISMARA results: FOXL1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOXL1

Z-value: 1.71

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Transcription factors associated with FOXL1

Gene Symbol	Gene ID	Gene Info
FOXL1 Ensembl NCBI GeneCards UniProt	ENSG00000176678.6	FOXL1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXL1	hg38_v1_chr16_+_86578543_86578555	0.37	2.3e-08	Click!

Activity profile of FOXL1 motif

Sorted Z-values of FOXL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXL1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr2_+_90069662 Show fit	52.21	ENST00000390271.2	IGKV6D-41 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6D-41 (non-functional)
chr2_-_89160329 Show fit	47.50	ENST00000390256.2	IGKV6-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6-21 (non-functional)
chr12_+_69348372 Show fit	46.02	ENST00000261267.7 ENST00000549690.1 ENST00000548839.1	LYZ Ensembl NCBI GeneCards UniProt Show fit	lysozyme
chr12_-_91180365 Show fit	45.21	ENST00000547937.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr12_-_91179472 Show fit	39.62	ENST00000550099.5 ENST00000546391.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr2_-_88992903 Show fit	33.77	ENST00000495489.1	IGKV1-8 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-8
chr6_+_33080445 Show fit	33.76	ENST00000428835.5	HLA-DPB1 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DP beta 1
chr12_-_91179517 Show fit	30.25	ENST00000551354.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr22_+_22900976 Show fit	30.20	ENST00000390323.2	IGLC2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 2
chr2_+_90021567 Show fit	29.09	ENST00000436451.2	IGKV6D-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6D-21 (non-functional)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	608.2	GO:0006958	complement activation, classical pathway(GO:0006958)
1.6	273.7	GO:0002377	immunoglobulin production(GO:0002377)
14.7	190.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
7.0	84.2	GO:0006069	ethanol oxidation(GO:0006069)
0.3	76.9	GO:0002250	adaptive immune response(GO:0002250)
0.6	58.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.7	48.0	GO:0032729	positive regulation of interferon-gamma production(GO:0032729)
9.2	46.0	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
10.1	40.3	GO:0002399	MHC class II protein complex assembly(GO:0002399)
9.7	29.0	GO:0071461	cellular response to redox state(GO:0071461)

Showing 1 to 10 of 326 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	521.0	GO:0005615	extracellular space(GO:0005615)
4.8	237.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
1.2	210.7	GO:0072562	blood microparticle(GO:0072562)
14.7	190.7	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
5.6	105.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.3	49.6	GO:0009897	external side of plasma membrane(GO:0009897)
14.0	41.9	GO:0071756	IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.5	41.9	GO:0035580	specific granule lumen(GO:0035580)
0.4	33.9	GO:0005791	rough endoplasmic reticulum(GO:0005791)
7.7	30.6	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)

Showing 1 to 10 of 112 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	988.4	GO:0003823	antigen binding(GO:0003823)
2.2	184.1	GO:0050840	extracellular matrix binding(GO:0050840)
10.5	84.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
7.7	46.0	GO:0003796	lysozyme activity(GO:0003796)
0.5	44.6	GO:0004984	olfactory receptor activity(GO:0004984)
4.4	30.6	GO:0030492	hemoglobin binding(GO:0030492)
0.2	29.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
3.6	29.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6	28.4	GO:0005044	scavenger receptor activity(GO:0005044)
5.4	27.1	GO:0019862	IgA binding(GO:0019862)

Showing 1 to 10 of 255 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	209.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	61.1	PID CMYB PATHWAY	C-MYB transcription factor network
0.3	58.2	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1	39.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	36.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.7	31.8	NABA COLLAGENS	Genes encoding collagen proteins
0.1	23.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	20.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	18.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	16.7	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway

Showing 1 to 10 of 68 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.1	190.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
4.5	94.3	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
8.4	84.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
1.3	60.9	REACTOME AMYLOIDS	Genes involved in Amyloids
0.6	55.6	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.4	39.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5	38.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	34.9	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	31.0	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	29.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 106 entries

Results for FOXL1

Z-value: 1.71

Motif logo

Transcription factors associated with FOXL1

Activity-expression correlation:

Activity profile of FOXL1 motif

Sorted Z-values of FOXL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXL1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: