Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for FOXM1_TBL1XR1
Z-value: 2.17
Motif logo
Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXM1 | hg38_v1_chr12_-_2877113_2877182, hg38_v1_chr12_-_2876986_2877092 | -0.44 | 1.7e-11 | Click! |
| TBL1XR1 | hg38_v1_chr3_-_177197429_177197492, hg38_v1_chr3_-_177196451_177196489, hg38_v1_chr3_-_177197210_177197233 | -0.38 | 7.4e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.5 | 410.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 4.0 | 400.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 2.1 | 112.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.9 | 105.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.1 | 95.9 | GO:0098743 | cell aggregation(GO:0098743) |
| 4.6 | 91.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 4.9 | 87.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 1.1 | 84.8 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.6 | 82.6 | GO:0007601 | visual perception(GO:0007601) |
| 2.3 | 72.3 | GO:0015695 | organic cation transport(GO:0015695) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 710.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 671.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 530.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 33.0 | 429.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.8 | 225.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.0 | 181.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 160.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.0 | 124.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 6.5 | 103.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 7.3 | 95.4 | GO:0005833 | hemoglobin complex(GO:0005833) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 813.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 5.4 | 474.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 3.8 | 353.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.2 | 305.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.9 | 194.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.8 | 163.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 4.3 | 128.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.1 | 107.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 90.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 1.0 | 88.9 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 441.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.0 | 379.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.3 | 376.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.3 | 295.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.0 | 176.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.9 | 53.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.5 | 50.2 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 1.2 | 49.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.9 | 48.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.7 | 45.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 472.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 14.7 | 396.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 3.8 | 345.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 1.3 | 171.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.2 | 158.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 2.0 | 117.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.1 | 72.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.0 | 72.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.5 | 71.6 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 1.2 | 68.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |