ISMARA results: FOXN1

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for FOXN1

Z-value: 0.83

Motif logo

Transcription factors associated with FOXN1

Gene Symbol	Gene ID	Gene Info
FOXN1 Ensembl NCBI GeneCards UniProt	ENSG00000109101.8	FOXN1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXN1	hg38_v1_chr17_+_28506320_28506360	-0.46	6.4e-13	Click!

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr19_-_42302690 Show fit	13.67	ENST00000596265.5	PAFAH1B3 Ensembl NCBI GeneCards UniProt Show fit	platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr19_-_42302576 Show fit	13.27	ENST00000262890.8	PAFAH1B3 Ensembl NCBI GeneCards UniProt Show fit	platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr15_+_65869974 Show fit	13.11	ENST00000567671.1	RAB11A Ensembl NCBI GeneCards UniProt Show fit	RAB11A, member RAS oncogene family
chr19_-_42302766 Show fit	12.64	ENST00000595530.5 ENST00000538771.5 ENST00000601865.5	PAFAH1B3 Ensembl NCBI GeneCards UniProt Show fit	platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr1_-_8878706 Show fit	11.91	ENST00000646156.1	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1
chr14_+_54397021 Show fit	10.62	ENST00000541304.5	CDKN3 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase inhibitor 3
chr1_-_8878646 Show fit	10.50	ENST00000643438.1	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1
chr12_+_69239592 Show fit	10.26	ENST00000456847.7 ENST00000266679.8	CPSF6 Ensembl NCBI GeneCards UniProt Show fit	cleavage and polyadenylation specific factor 6
chr14_+_54396949 Show fit	9.86	ENST00000611205.4	CDKN3 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase inhibitor 3
chr14_+_54396964 Show fit	9.75	ENST00000543789.6 ENST00000442975.6 ENST00000458126.6 ENST00000556102.6 ENST00000335183.11	CDKN3 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase inhibitor 3

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.7	40.4	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.4	28.8	GO:0043631	mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1	28.2	GO:0016042	lipid catabolic process(GO:0016042)
0.3	27.9	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
5.6	22.5	GO:0010796	regulation of multivesicular body size(GO:0010796)
1.4	16.3	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.4	16.2	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.5	15.5	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
3.8	15.1	GO:0007113	endomitotic cell cycle(GO:0007113)
1.2	12.8	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)

Showing 1 to 10 of 137 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
5.0	40.4	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
2.7	24.7	GO:0042382	paraspeckles(GO:0042382)
4.5	22.5	GO:0098837	postsynaptic recycling endosome(GO:0098837)
0.0	19.0	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
1.6	18.8	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	16.9	GO:0016607	nuclear speck(GO:0016607)
0.7	15.1	GO:0032433	filopodium tip(GO:0032433)
1.3	14.0	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.3	13.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.8	12.8	GO:0005642	annulate lamellae(GO:0005642)

Showing 1 to 10 of 94 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
5.0	40.4	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
7.0	35.0	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
0.4	25.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.9	22.5	GO:0031489	myosin V binding(GO:0031489)
0.4	16.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
5.0	15.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.9	14.2	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
3.5	14.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.1	13.9	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.9	12.8	GO:0005049	nuclear export signal receptor activity(GO:0005049)

Showing 1 to 10 of 110 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	36.8	PID NOTCH PATHWAY	Notch signaling pathway
0.7	35.0	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.6	30.4	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.7	21.7	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	16.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.7	13.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	9.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	9.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	8.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	7.8	PID FANCONI PATHWAY	Fanconi anemia pathway

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	40.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	25.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.2	19.0	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.5	18.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.5	16.5	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.9	14.0	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.4	12.8	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2	11.3	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1	10.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	10.3	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6

Showing 1 to 10 of 51 entries

Results for FOXN1

Z-value: 0.83

Motif logo

Transcription factors associated with FOXN1

Activity-expression correlation:

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: