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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXO3_FOXD2
Z-value: 1.04
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Transcription factors associated with FOXO3_FOXD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXD2 | hg38_v1_chr1_+_47438036_47438112 | -0.27 | 5.3e-05 | Click! |
| FOXO3 | hg38_v1_chr6_+_108559742_108559835, hg38_v1_chr6_+_108560906_108560970 | -0.15 | 2.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO3_FOXD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 53.8 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 3.3 | 50.0 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.7 | 48.4 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 3.2 | 42.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 9.1 | 36.5 | GO:0090095 | metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 3.0 | 35.4 | GO:0021840 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.5 | 35.0 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 11.3 | 33.8 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.9 | 31.6 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.5 | 30.6 | GO:0051865 | protein autoubiquitination(GO:0051865) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 71.7 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 9.0 | 53.8 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 10.0 | 50.0 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 3.2 | 42.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.3 | 35.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 33.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 33.3 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.7 | 33.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.5 | 32.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.7 | 28.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 53.8 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.4 | 47.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.9 | 42.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 3.2 | 38.2 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.4 | 37.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 2.0 | 36.5 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 1.2 | 35.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 3.1 | 33.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.8 | 33.0 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 7.5 | 30.2 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 98.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.9 | 66.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 47.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.3 | 41.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.8 | 38.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 1.0 | 33.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 1.2 | 30.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.6 | 30.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 24.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.6 | 20.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 77.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 1.3 | 62.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.9 | 52.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.6 | 44.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 2.8 | 42.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.4 | 39.5 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 1.2 | 37.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 1.1 | 35.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 30.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.0 | 30.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |