ISMARA results: FOXO4

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOXO4

Z-value: 1.27

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Transcription factors associated with FOXO4

Gene Symbol	Gene ID	Gene Info
FOXO4 Ensembl NCBI GeneCards UniProt	ENSG00000184481.17	FOXO4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXO4	hg38_v1_chrX_+_71095838_71095860	0.60	6.2e-23	Click!

Activity profile of FOXO4 motif

Sorted Z-values of FOXO4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO4

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Promoter	Score	Transcript	Gene	Gene Info
chr9_+_127611760 Show fit	30.57	ENST00000625363.2 ENST00000626539.3	STXBP1 Ensembl NCBI GeneCards UniProt Show fit	syntaxin binding protein 1
chr5_-_42811884 Show fit	30.21	ENST00000514985.6 ENST00000511224.5 ENST00000507920.5 ENST00000510965.1	SELENOP Ensembl NCBI GeneCards UniProt Show fit	selenoprotein P
chr5_-_131796921 Show fit	29.27	ENST00000307968.11 ENST00000307954.12	FNIP1 Ensembl NCBI GeneCards UniProt Show fit	folliculin interacting protein 1
chr5_-_131797030 Show fit	26.52	ENST00000615660.4	FNIP1 Ensembl NCBI GeneCards UniProt Show fit	folliculin interacting protein 1
chr14_-_59630582 Show fit	26.39	ENST00000395090.5	RTN1 Ensembl NCBI GeneCards UniProt Show fit	reticulon 1
chr16_+_6019585 Show fit	25.58	ENST00000547372.5	RBFOX1 Ensembl NCBI GeneCards UniProt Show fit	RNA binding fox-1 homolog 1
chr1_-_182391783 Show fit	25.25	ENST00000331872.11 ENST00000339526.8	GLUL Ensembl NCBI GeneCards UniProt Show fit	glutamate-ammonia ligase
chr1_-_182391323 Show fit	24.31	ENST00000642379.1	GLUL Ensembl NCBI GeneCards UniProt Show fit	glutamate-ammonia ligase
chr2_-_71227055 Show fit	23.65	ENST00000244221.9	PAIP2B Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein interacting protein 2B
chr1_+_92080305 Show fit	23.17	ENST00000342818.4 ENST00000636805.2	BTBD8 Ensembl NCBI GeneCards UniProt Show fit	BTB domain containing 8

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
18.1	72.5	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.8	64.7	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
12.0	60.1	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.4	34.8	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.9	33.4	GO:0048665	neuron fate specification(GO:0048665)
7.7	31.0	GO:1903294	regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
3.8	30.2	GO:0001887	selenium compound metabolic process(GO:0001887)
2.8	28.2	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
3.4	23.8	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.3	23.1	GO:0034389	lipid particle organization(GO:0034389)

Showing 1 to 10 of 154 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	72.5	GO:0097386	glial cell projection(GO:0097386)
0.2	48.2	GO:0005802	trans-Golgi network(GO:0005802)
0.3	43.7	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.5	38.6	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5	38.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.4	32.9	GO:0005776	autophagosome(GO:0005776)
5.1	30.6	GO:0048787	presynaptic active zone membrane(GO:0048787)
1.5	30.2	GO:0031089	platelet dense granule lumen(GO:0031089)
2.2	28.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2	24.4	GO:0017053	transcriptional repressor complex(GO:0017053)

Showing 1 to 10 of 88 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
18.1	72.5	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2	69.9	GO:0008022	protein C-terminus binding(GO:0008022)
15.0	60.1	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.3	51.2	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2	36.8	GO:0005521	lamin binding(GO:0005521)
3.9	31.4	GO:0004111	creatine kinase activity(GO:0004111)
1.5	30.6	GO:0043274	phospholipase binding(GO:0043274)
2.5	30.2	GO:0008430	selenium binding(GO:0008430)
0.9	28.6	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.1	23.7	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)

Showing 1 to 10 of 109 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	28.6	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.3	20.9	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	17.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	15.7	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	14.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	12.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	10.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	10.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	10.0	PID SHP2 PATHWAY	SHP2 signaling
0.2	9.7	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	72.5	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
2.0	43.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.4	28.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.6	28.2	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	23.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.4	15.7	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2	13.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	12.4	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.3	12.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	11.9	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport

Showing 1 to 10 of 51 entries

Results for FOXO4

Z-value: 1.27

Motif logo

Transcription factors associated with FOXO4

Activity-expression correlation:

Activity profile of FOXO4 motif

Sorted Z-values of FOXO4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO4

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: