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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FOXQ1
Z-value: 0.97
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Transcription factors associated with FOXQ1
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXQ1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 29.5 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 7.4 | 29.5 | GO:0002188 | translation reinitiation(GO:0002188) |
| 1.8 | 27.0 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 3.2 | 25.6 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 3.4 | 23.5 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 4.5 | 22.7 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.4 | 21.6 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 2.2 | 20.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.7 | 20.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 1.0 | 19.3 | GO:0008228 | opsonization(GO:0008228) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 44.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 40.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 3.7 | 29.5 | GO:0005827 | polar microtubule(GO:0005827) |
| 2.2 | 26.7 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 25.5 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.3 | 25.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 24.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 3.4 | 23.5 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.8 | 17.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 17.4 | GO:0005819 | spindle(GO:0005819) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 30.4 | GO:0005198 | structural molecule activity(GO:0005198) |
| 9.8 | 29.5 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.6 | 27.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.7 | 27.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 3.2 | 25.6 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.4 | 24.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 5.7 | 22.7 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 1.0 | 20.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 20.1 | GO:0019894 | kinesin binding(GO:0019894) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 29.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.3 | 23.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 19.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 18.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.4 | 14.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.3 | 14.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.3 | 13.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 13.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 13.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.4 | 12.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.4 | 27.0 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 2.4 | 26.7 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.8 | 25.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 1.5 | 22.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.8 | 20.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 1.1 | 20.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.6 | 17.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 17.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 16.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |