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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FUBP1
Z-value: 0.59
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Transcription factors associated with FUBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FUBP1 | hg38_v1_chr1_-_77979054_77979116 | -0.25 | 2.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FUBP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 26.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.1 | 22.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 9.6 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.3 | 9.5 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.9 | 6.4 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.2 | 6.4 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.0 | 6.3 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 1.5 | 6.2 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.9 | 6.1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.9 | 6.0 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 26.5 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.8 | 14.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 13.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.4 | 9.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.4 | 8.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 8.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 6.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.1 | 6.4 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 6.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 5.8 | GO:0005719 | nuclear euchromatin(GO:0005719) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 9.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 8.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.4 | 8.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.8 | 6.4 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.7 | 6.4 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.5 | 6.3 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 1.0 | 6.2 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 1.2 | 6.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 6.0 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 26.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 14.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 13.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 10.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 9.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 8.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 5.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 4.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 3.9 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 26.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 14.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 10.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.5 | 9.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 6.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 6.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.3 | 6.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 5.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 4.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 4.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |