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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GAAAUGU
Z-value: 0.67
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miRNA associated with seed GAAAUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-203a-3p.1
|
Network of associatons between targets according to the STRING database.
First level regulatory network of GAAAUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.5 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.1 | 8.1 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.4 | 7.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.1 | 5.7 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 5.7 | GO:0043486 | histone exchange(GO:0043486) |
| 0.3 | 5.5 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 1.3 | 5.3 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.4 | 5.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.7 | 5.1 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 0.3 | 4.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 9.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.5 | 8.5 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 8.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 1.9 | 7.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 6.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 6.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 5.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.3 | 5.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.6 | 5.2 | GO:0097452 | GAIT complex(GO:0097452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.5 | 8.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.3 | 8.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 7.7 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 1.9 | 7.4 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 5.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.4 | 5.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 4.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 4.4 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 4.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 8.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 7.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 6.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 5.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.8 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 4.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 7.6 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.2 | 7.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 5.9 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.1 | 4.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 3.9 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 3.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.2 | 3.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 3.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |