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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GAGGUAG
Z-value: 2.10
Motif logo
miRNA associated with seed GAGGUAG
| Name | miRBASE accession |
|---|---|
|
hsa-let-7a-5p
|
MIMAT0000062 |
|
hsa-let-7b-5p
|
MIMAT0000063 |
|
hsa-let-7c-5p
|
MIMAT0000064 |
|
hsa-let-7d-5p
|
MIMAT0000065 |
|
hsa-let-7e-5p
|
MIMAT0000066 |
|
hsa-let-7f-5p
|
MIMAT0000067 |
|
hsa-let-7g-5p
|
MIMAT0000414 |
|
hsa-let-7i-5p
|
MIMAT0000415 |
|
hsa-miR-4458
|
MIMAT0018980 |
|
hsa-miR-4500
|
MIMAT0019036 |
|
hsa-miR-98-5p
|
MIMAT0000096 |
Activity profile of GAGGUAG motif
Sorted Z-values of GAGGUAG motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GAGGUAG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 51.7 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 8.0 | 32.0 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 7.5 | 67.8 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 7.4 | 22.2 | GO:0002025 | vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) |
| 7.1 | 49.8 | GO:0051013 | microtubule severing(GO:0051013) |
| 7.0 | 21.1 | GO:0019859 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 6.3 | 19.0 | GO:1990168 | protein K33-linked deubiquitination(GO:1990168) |
| 5.9 | 17.7 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 5.9 | 17.6 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 5.9 | 17.6 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 5.8 | 28.9 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 5.7 | 17.2 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 5.6 | 16.7 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 5.6 | 33.4 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 5.3 | 21.4 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 5.2 | 30.9 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 5.0 | 20.1 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 4.8 | 19.3 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 4.8 | 14.3 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 4.7 | 14.0 | GO:0098528 | skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809) |
| 4.5 | 13.5 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
| 4.2 | 12.7 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 4.2 | 12.5 | GO:0051136 | regulation of extrathymic T cell differentiation(GO:0033082) regulation of NK T cell differentiation(GO:0051136) sebum secreting cell proliferation(GO:1990654) |
| 4.0 | 11.9 | GO:0009386 | translational attenuation(GO:0009386) |
| 3.9 | 23.5 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 3.7 | 40.4 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 3.6 | 3.6 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 3.5 | 10.4 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 3.2 | 9.7 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154) |
| 3.2 | 9.5 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 3.1 | 12.5 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 3.1 | 3.1 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) |
| 3.0 | 12.1 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 2.9 | 40.6 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 2.9 | 17.3 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 2.7 | 24.2 | GO:0090649 | response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 2.7 | 15.9 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 2.7 | 10.6 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 2.6 | 21.0 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 2.5 | 7.6 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 2.5 | 7.6 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 2.4 | 31.4 | GO:0015074 | DNA integration(GO:0015074) |
| 2.4 | 12.0 | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 2.4 | 7.2 | GO:1905071 | occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075) |
| 2.3 | 6.9 | GO:0010752 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752) negative regulation of endothelial cell chemotaxis(GO:2001027) |
| 2.3 | 16.0 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 2.3 | 15.9 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 2.2 | 9.0 | GO:0016095 | polyprenol catabolic process(GO:0016095) |
| 2.2 | 8.8 | GO:0021759 | globus pallidus development(GO:0021759) |
| 2.2 | 39.4 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 2.2 | 21.5 | GO:0080182 | DNA methylation involved in embryo development(GO:0043045) histone H3-K4 trimethylation(GO:0080182) changes to DNA methylation involved in embryo development(GO:1901538) |
| 2.1 | 4.2 | GO:0002329 | pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) |
| 2.0 | 12.2 | GO:0016926 | protein desumoylation(GO:0016926) |
| 2.0 | 6.0 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 2.0 | 10.0 | GO:0001555 | oocyte growth(GO:0001555) |
| 2.0 | 6.0 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 2.0 | 5.9 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
| 1.9 | 3.9 | GO:0071879 | positive regulation of adrenergic receptor signaling pathway(GO:0071879) |
| 1.9 | 3.9 | GO:0046666 | retinal cell programmed cell death(GO:0046666) |
| 1.9 | 30.9 | GO:0050942 | positive regulation of pigment cell differentiation(GO:0050942) |
| 1.9 | 9.5 | GO:0016240 | autophagosome docking(GO:0016240) |
| 1.9 | 5.7 | GO:0048865 | stem cell fate commitment(GO:0048865) |
| 1.9 | 5.6 | GO:0007525 | somatic muscle development(GO:0007525) convergent extension involved in axis elongation(GO:0060028) |
| 1.8 | 29.3 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 1.7 | 5.2 | GO:1903059 | regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) |
| 1.7 | 10.3 | GO:0072367 | regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) |
| 1.7 | 5.1 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 1.7 | 10.2 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 1.7 | 21.6 | GO:0030202 | heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 1.6 | 13.2 | GO:0070166 | enamel mineralization(GO:0070166) |
| 1.6 | 4.9 | GO:0051040 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of calcium-independent cell-cell adhesion(GO:0051040) corticotropin hormone secreting cell differentiation(GO:0060128) |
| 1.6 | 9.8 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 1.6 | 8.1 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 1.6 | 6.4 | GO:1990637 | response to prolactin(GO:1990637) |
| 1.6 | 11.2 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 1.6 | 12.8 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 1.6 | 12.7 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 1.6 | 20.3 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 1.6 | 17.1 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 1.6 | 4.7 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 1.5 | 13.7 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 1.5 | 4.5 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.5 | 11.8 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 1.4 | 18.8 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 1.4 | 4.2 | GO:0036166 | cell migration involved in kidney development(GO:0035787) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) phenotypic switching(GO:0036166) negative regulation of phospholipid biosynthetic process(GO:0071072) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of phenotypic switching(GO:1900239) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591) |
| 1.4 | 8.2 | GO:0048318 | axial mesoderm development(GO:0048318) |
| 1.3 | 5.3 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 1.3 | 4.0 | GO:0019075 | virus maturation(GO:0019075) |
| 1.3 | 7.9 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 1.3 | 21.1 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 1.2 | 18.6 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 1.2 | 14.7 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 1.2 | 15.1 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 1.1 | 6.9 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 1.1 | 4.5 | GO:0035977 | protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382) |
| 1.1 | 35.0 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 1.1 | 4.5 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 1.1 | 9.0 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 1.1 | 5.3 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 1.0 | 9.4 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 1.0 | 6.0 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
| 1.0 | 5.0 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 1.0 | 6.8 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 1.0 | 10.6 | GO:0034312 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 1.0 | 3.8 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.9 | 17.9 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.9 | 9.3 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.9 | 5.6 | GO:0050893 | sensory processing(GO:0050893) |
| 0.9 | 2.7 | GO:0090230 | regulation of centromere complex assembly(GO:0090230) |
| 0.9 | 3.6 | GO:0021571 | rhombomere 5 development(GO:0021571) |
| 0.9 | 2.7 | GO:0006683 | galactosylceramide catabolic process(GO:0006683) |
| 0.9 | 5.3 | GO:0075071 | autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071) |
| 0.9 | 19.1 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.9 | 6.1 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.9 | 2.6 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.9 | 11.1 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.8 | 7.5 | GO:0060346 | bone trabecula formation(GO:0060346) |
| 0.8 | 8.9 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.8 | 2.4 | GO:1901860 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) response to norepinephrine(GO:0071873) positive regulation of mitochondrial DNA metabolic process(GO:1901860) regulation of progesterone biosynthetic process(GO:2000182) |
| 0.8 | 6.3 | GO:0010533 | regulation of activation of Janus kinase activity(GO:0010533) |
| 0.8 | 4.7 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.8 | 9.4 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.8 | 12.5 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.8 | 11.7 | GO:0043586 | tongue development(GO:0043586) |
| 0.8 | 10.9 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.8 | 6.9 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 0.8 | 3.1 | GO:0019086 | late viral transcription(GO:0019086) |
| 0.8 | 3.8 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.8 | 2.3 | GO:0043016 | negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017) |
| 0.7 | 20.9 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.7 | 8.1 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.7 | 13.2 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.7 | 4.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.7 | 7.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.7 | 17.2 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.7 | 3.6 | GO:0019464 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.7 | 4.9 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.7 | 2.8 | GO:0010748 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.7 | 6.2 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.7 | 2.1 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.7 | 4.8 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.7 | 13.0 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.7 | 3.4 | GO:0033504 | floor plate development(GO:0033504) |
| 0.6 | 14.1 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.6 | 21.6 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.6 | 20.3 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.6 | 22.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.6 | 1.9 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.6 | 12.7 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.6 | 13.1 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.6 | 24.4 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.6 | 0.6 | GO:1905069 | negative regulation of mononuclear cell migration(GO:0071676) allantois development(GO:1905069) |
| 0.6 | 9.2 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.6 | 1.1 | GO:0051461 | positive regulation of corticotropin secretion(GO:0051461) |
| 0.5 | 4.8 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.5 | 10.4 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.5 | 3.1 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.5 | 4.0 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.5 | 9.5 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.5 | 6.9 | GO:0045955 | negative regulation of calcium ion-dependent exocytosis(GO:0045955) |
| 0.5 | 2.9 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.5 | 4.2 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.4 | 5.8 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 3.1 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.4 | 8.4 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.4 | 6.9 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.4 | 5.2 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.4 | 9.4 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.4 | 3.8 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
| 0.4 | 16.5 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.4 | 2.9 | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052) |
| 0.4 | 2.1 | GO:0002442 | serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.4 | 10.2 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.4 | 6.9 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.4 | 4.8 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.4 | 11.3 | GO:0007616 | long-term memory(GO:0007616) |
| 0.4 | 1.6 | GO:1904306 | regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306) |
| 0.4 | 4.3 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.4 | 19.3 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.4 | 12.6 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.4 | 9.1 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.4 | 20.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.4 | 4.8 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.4 | 5.8 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.4 | 6.5 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.4 | 19.3 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.3 | 14.5 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.3 | 7.7 | GO:0042501 | serine phosphorylation of STAT protein(GO:0042501) |
| 0.3 | 9.0 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.3 | 15.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.3 | 12.8 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.3 | 11.0 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.3 | 1.2 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.3 | 3.4 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.3 | 11.1 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
| 0.3 | 4.2 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.3 | 14.9 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.3 | 2.2 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.3 | 3.3 | GO:0045724 | positive regulation of cilium assembly(GO:0045724) |
| 0.3 | 6.7 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.3 | 7.1 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.3 | 5.8 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.3 | 1.5 | GO:0015853 | adenine transport(GO:0015853) |
| 0.2 | 19.5 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.2 | 2.4 | GO:0060850 | regulation of transcription involved in cell fate commitment(GO:0060850) |
| 0.2 | 8.2 | GO:1901998 | toxin transport(GO:1901998) |
| 0.2 | 12.0 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.2 | 5.1 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.2 | 1.1 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.2 | 4.7 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.2 | 9.8 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.2 | 10.5 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.2 | 5.4 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.2 | 2.1 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.2 | 13.8 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.2 | 4.1 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.2 | 3.1 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.2 | 7.3 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.2 | 13.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 2.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.2 | 4.2 | GO:0097503 | sialylation(GO:0097503) |
| 0.2 | 6.3 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.2 | 7.1 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.2 | 9.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.2 | 0.5 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.2 | 5.7 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.2 | 8.9 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.2 | 13.6 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.2 | 16.2 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.2 | 3.6 | GO:0034629 | cellular protein complex localization(GO:0034629) |
| 0.2 | 7.6 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.2 | 3.9 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.2 | 0.8 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.2 | 14.2 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.1 | 2.8 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.1 | 1.5 | GO:0023019 | signal transduction involved in regulation of gene expression(GO:0023019) |
| 0.1 | 1.5 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.1 | 8.9 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 1.5 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.1 | 5.0 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.1 | 16.2 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.1 | 5.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.5 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.1 | 1.4 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.1 | 0.8 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 1.8 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.1 | 1.7 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 23.3 | GO:0007601 | visual perception(GO:0007601) |
| 0.1 | 6.6 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
| 0.1 | 6.1 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.1 | 5.2 | GO:0048477 | oogenesis(GO:0048477) |
| 0.1 | 6.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 4.2 | GO:0034308 | primary alcohol metabolic process(GO:0034308) |
| 0.1 | 2.5 | GO:0010830 | regulation of myotube differentiation(GO:0010830) |
| 0.1 | 3.0 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.1 | 2.3 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 7.2 | GO:0031623 | receptor internalization(GO:0031623) |
| 0.1 | 0.4 | GO:0051043 | regulation of membrane protein ectodomain proteolysis(GO:0051043) |
| 0.1 | 2.1 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.1 | 0.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 5.0 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.1 | 1.5 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 1.1 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 5.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 6.2 | GO:0007626 | locomotory behavior(GO:0007626) |
| 0.0 | 4.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 1.1 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 3.4 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.2 | GO:0009082 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.0 | 0.0 | GO:0009826 | unidimensional cell growth(GO:0009826) |
| 0.0 | 4.3 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 8.6 | GO:0007283 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.0 | 3.7 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.0 | 10.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 3.1 | GO:0007163 | establishment or maintenance of cell polarity(GO:0007163) |
| 0.0 | 2.4 | GO:0006310 | DNA recombination(GO:0006310) |
| 0.0 | 0.6 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 33.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 4.9 | 14.7 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 4.7 | 19.0 | GO:0070695 | FHF complex(GO:0070695) |
| 4.3 | 13.0 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 4.2 | 12.7 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 4.0 | 52.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 4.0 | 67.8 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 3.6 | 21.5 | GO:0001940 | male pronucleus(GO:0001940) |
| 3.4 | 17.2 | GO:0044308 | axonal spine(GO:0044308) |
| 3.2 | 19.0 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 2.3 | 25.2 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 2.3 | 15.9 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 2.2 | 6.7 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 2.0 | 5.9 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
| 1.9 | 30.9 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 1.9 | 11.3 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 1.8 | 12.9 | GO:0005683 | U7 snRNP(GO:0005683) |
| 1.8 | 15.9 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
| 1.7 | 5.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 1.6 | 9.7 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 1.6 | 12.8 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 1.6 | 10.9 | GO:0036157 | outer dynein arm(GO:0036157) |
| 1.4 | 24.8 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 1.3 | 20.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 1.3 | 21.1 | GO:0016600 | flotillin complex(GO:0016600) |
| 1.3 | 5.2 | GO:0048179 | activin receptor complex(GO:0048179) |
| 1.2 | 5.0 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 1.2 | 7.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 1.2 | 9.5 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 1.2 | 17.6 | GO:0030478 | actin cap(GO:0030478) |
| 1.1 | 4.4 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 1.1 | 21.4 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.9 | 10.0 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.9 | 2.7 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.9 | 4.5 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.8 | 3.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.8 | 3.9 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.7 | 21.7 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.7 | 17.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.7 | 8.9 | GO:0016342 | catenin complex(GO:0016342) |
| 0.7 | 4.7 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.7 | 15.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.6 | 10.4 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.6 | 9.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.6 | 3.8 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.6 | 9.9 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.6 | 6.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 2.1 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.5 | 2.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.5 | 3.4 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.5 | 5.8 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.4 | 3.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.4 | 1.8 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.4 | 4.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.4 | 11.3 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.4 | 3.0 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.4 | 12.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.4 | 3.2 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.4 | 9.7 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.4 | 7.3 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.4 | 17.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.3 | 3.1 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.3 | 49.2 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 4.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 10.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.3 | 8.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.3 | 6.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 7.2 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 4.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 4.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 2.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.2 | 14.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 28.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.2 | 12.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 0.4 | GO:0043196 | varicosity(GO:0043196) |
| 0.2 | 3.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.2 | 1.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.2 | 5.6 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.2 | 4.8 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.2 | 17.5 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 27.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 13.1 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.2 | 11.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 18.2 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.2 | 11.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 75.7 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.2 | 19.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 28.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 1.1 | GO:0051286 | cell tip(GO:0051286) |
| 0.2 | 8.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.2 | 1.4 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.2 | 15.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 39.7 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 28.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 5.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 45.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 8.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 5.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 9.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 5.7 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.1 | 7.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 54.5 | GO:0005874 | microtubule(GO:0005874) |
| 0.1 | 3.6 | GO:0030120 | vesicle coat(GO:0030120) |
| 0.1 | 11.9 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.1 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.1 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 7.6 | GO:0005903 | brush border(GO:0005903) |
| 0.1 | 15.8 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 6.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 13.1 | GO:0043296 | bicellular tight junction(GO:0005923) apical junction complex(GO:0043296) |
| 0.1 | 2.6 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.1 | 0.8 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.1 | 19.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 8.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 8.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 11.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 6.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 33.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 3.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 25.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 15.4 | GO:0043235 | receptor complex(GO:0043235) |
| 0.1 | 11.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 7.3 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.1 | 6.4 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 2.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.6 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 1.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 3.6 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 2.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.6 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 22.0 | GO:0005615 | extracellular space(GO:0005615) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.8 | 51.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 9.9 | 39.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 7.4 | 22.2 | GO:0004939 | beta-adrenergic receptor activity(GO:0004939) |
| 7.1 | 49.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 6.3 | 19.0 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 6.3 | 18.8 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 5.9 | 35.3 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 5.8 | 34.9 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 5.4 | 21.6 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 5.3 | 68.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 4.8 | 14.3 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 3.9 | 19.6 | GO:0004803 | transposase activity(GO:0004803) |
| 3.6 | 10.7 | GO:0047322 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405) |
| 3.5 | 10.4 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 3.3 | 13.0 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 3.1 | 37.7 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 3.0 | 12.1 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 3.0 | 9.0 | GO:0033765 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751) |
| 2.9 | 11.8 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 2.7 | 32.0 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 2.7 | 16.0 | GO:1904047 | S-adenosyl-L-methionine binding(GO:1904047) |
| 2.3 | 21.1 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 2.3 | 6.9 | GO:0070052 | collagen V binding(GO:0070052) |
| 2.2 | 24.3 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 2.0 | 12.2 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 1.9 | 11.6 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 1.9 | 9.4 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 1.8 | 30.5 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 1.8 | 5.3 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 1.8 | 10.6 | GO:0017040 | ceramidase activity(GO:0017040) |
| 1.8 | 7.0 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 1.6 | 4.9 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 1.6 | 14.3 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 1.6 | 9.5 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 1.4 | 15.8 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 1.4 | 6.8 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 1.3 | 9.4 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 1.3 | 3.8 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 1.2 | 5.0 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 1.2 | 7.2 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 1.2 | 4.8 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 1.2 | 3.6 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 1.2 | 5.9 | GO:0016890 | site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890) |
| 1.1 | 27.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 1.1 | 3.4 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 1.1 | 15.9 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 1.1 | 59.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 1.0 | 5.0 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 1.0 | 3.0 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 1.0 | 4.9 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 1.0 | 14.7 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 1.0 | 21.1 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 1.0 | 3.8 | GO:0097001 | glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001) |
| 0.9 | 3.8 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.9 | 11.1 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.9 | 4.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.9 | 2.7 | GO:0004336 | galactosylceramidase activity(GO:0004336) |
| 0.9 | 9.0 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.9 | 2.6 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.8 | 7.5 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.8 | 29.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.8 | 27.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.8 | 3.9 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.8 | 10.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.8 | 8.4 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.8 | 17.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.8 | 4.5 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.7 | 17.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.7 | 6.0 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.7 | 5.2 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.7 | 23.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.7 | 15.3 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.7 | 12.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.7 | 4.8 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.7 | 8.1 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.7 | 19.0 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.7 | 9.5 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.7 | 2.0 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
| 0.6 | 3.9 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.6 | 4.5 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.6 | 20.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.6 | 7.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.6 | 6.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.6 | 4.2 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.6 | 5.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.6 | 5.1 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.6 | 19.3 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.6 | 10.0 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.5 | 2.7 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.5 | 4.8 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.5 | 2.1 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.5 | 1.6 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.5 | 7.6 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.5 | 8.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.5 | 12.8 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.5 | 4.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.5 | 61.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 9.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.5 | 22.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.5 | 7.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.4 | 4.9 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.4 | 6.2 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.4 | 44.4 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.4 | 9.2 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.4 | 5.6 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.4 | 14.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.4 | 9.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.4 | 12.3 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.4 | 3.3 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.4 | 12.1 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.4 | 2.4 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.4 | 1.2 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.4 | 3.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.4 | 7.7 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.4 | 3.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.4 | 1.5 | GO:0015207 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 0.4 | 11.2 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.3 | 21.2 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.3 | 3.1 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 3.1 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.3 | 5.4 | GO:0005112 | Notch binding(GO:0005112) |
| 0.3 | 4.0 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.3 | 4.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.3 | 12.9 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.3 | 23.7 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.3 | 2.9 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.3 | 36.2 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.3 | 4.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.3 | 8.8 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.3 | 3.1 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.3 | 7.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.3 | 33.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.3 | 25.7 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.3 | 19.6 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.3 | 8.8 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.3 | 6.9 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 12.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.3 | 5.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.3 | 3.5 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.3 | 6.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 3.0 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.2 | 5.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 109.7 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.2 | 7.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 17.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 13.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 5.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 16.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 21.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 13.6 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.2 | 25.4 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.2 | 2.3 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.2 | 3.8 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.2 | 2.1 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 6.7 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.2 | 4.7 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 15.8 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.2 | 6.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 1.1 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.2 | 7.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.2 | 34.5 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.2 | 5.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 3.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 6.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 20.2 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.1 | 3.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 8.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 5.7 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 2.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 10.0 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 13.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 20.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 0.5 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 5.2 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 6.8 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.1 | 3.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 4.2 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.1 | 4.8 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.1 | 4.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 4.4 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 0.6 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 14.1 | GO:0005126 | cytokine receptor binding(GO:0005126) |
| 0.1 | 0.3 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.1 | 1.0 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 5.3 | GO:0005230 | extracellular ligand-gated ion channel activity(GO:0005230) |
| 0.1 | 3.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 2.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 11.0 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 2.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 1.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 11.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.9 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 11.1 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 11.2 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 3.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 3.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 2.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.8 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 7.4 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 1.7 | 80.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 1.2 | 13.5 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 1.0 | 6.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 1.0 | 33.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.9 | 17.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.9 | 10.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.9 | 62.8 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.7 | 20.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.7 | 7.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 20.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.6 | 5.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 14.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.5 | 26.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.5 | 8.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.5 | 9.5 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.4 | 9.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.4 | 16.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.4 | 18.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.4 | 15.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.4 | 18.9 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.4 | 26.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 9.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.3 | 2.6 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.3 | 16.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.3 | 6.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.3 | 8.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 13.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 31.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.3 | 7.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 10.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.3 | 9.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 11.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 8.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 6.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 3.8 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.2 | 19.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 20.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 3.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 6.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 14.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 4.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 7.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 11.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 7.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 2.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 3.8 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 5.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 1.2 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 14.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 2.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 0.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 6.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 11.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.9 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 0.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.6 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 40.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 2.3 | 39.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 1.6 | 23.5 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.4 | 21.7 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 1.4 | 23.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 1.4 | 27.2 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 1.2 | 22.2 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 1.1 | 5.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 1.0 | 17.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.9 | 11.8 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.9 | 9.0 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.9 | 12.4 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.8 | 20.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.8 | 22.2 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.8 | 12.5 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.8 | 21.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.7 | 15.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.7 | 7.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.7 | 20.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.7 | 26.7 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.6 | 32.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.6 | 9.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.6 | 8.2 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.6 | 40.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.6 | 9.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.6 | 13.0 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| 0.6 | 32.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 6.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.5 | 7.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.5 | 5.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.5 | 6.0 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.5 | 10.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.4 | 3.1 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.4 | 14.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.4 | 10.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.4 | 12.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 15.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 6.4 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.4 | 5.9 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.4 | 5.1 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.4 | 3.1 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.4 | 8.8 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.3 | 13.9 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.3 | 10.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 20.3 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.3 | 14.5 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.3 | 4.8 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.3 | 20.0 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.3 | 26.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 2.7 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.3 | 5.3 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.3 | 15.8 | REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | Genes involved in Negative regulation of FGFR signaling |
| 0.3 | 6.1 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.3 | 10.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 2.3 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.2 | 5.0 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 12.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 6.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 4.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 6.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.2 | 4.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.2 | 2.1 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.2 | 6.9 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.2 | 3.4 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.2 | 14.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 7.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 4.9 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 3.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 13.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 9.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 3.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 1.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 6.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 5.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 6.5 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.9 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 7.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.8 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.1 | 0.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 1.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 11.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 10.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 1.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.5 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 0.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |