ISMARA results: GATA1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GATA1_GATA4

Z-value: 2.12

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Transcription factors associated with GATA1_GATA4

Gene Symbol	Gene ID	Gene Info
GATA1 Ensembl NCBI GeneCards UniProt	ENSG00000102145.15	GATA1
GATA4 Ensembl NCBI GeneCards UniProt	ENSG00000136574.19	GATA4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA1	hg38_v1_chrX_+_48786578_48786597	0.60	1.1e-22	Click!
GATA4	hg38_v1_chr8_+_11676952_11676966	0.47	1.5e-13	Click!

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Promoter	Score	Transcript	Gene	Gene Info
chr15_-_43220989 Show fit	66.14	ENST00000540029.5 ENST00000441366.7 ENST00000648595.1	EPB42 Ensembl NCBI GeneCards UniProt Show fit	erythrocyte membrane protein band 4.2
chr12_-_54295748 Show fit	41.55	ENST00000540264.2 ENST00000312156.8	NFE2 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor, erythroid 2
chr1_+_25272439 Show fit	41.34	ENST00000648012.1	RHD Ensembl NCBI GeneCards UniProt Show fit	Rh blood group D antigen
chr1_+_25272492 Show fit	40.40	ENST00000454452.6	RHD Ensembl NCBI GeneCards UniProt Show fit	Rh blood group D antigen
chr19_-_13102848 Show fit	30.71	ENST00000264824.5	LYL1 Ensembl NCBI GeneCards UniProt Show fit	LYL1 basic helix-loop-helix family member
chr10_+_116545907 Show fit	30.34	ENST00000369221.2	PNLIP Ensembl NCBI GeneCards UniProt Show fit	pancreatic lipase
chr6_-_35797313 Show fit	28.17	ENST00000259938.7 ENST00000616014.3	CLPS Ensembl NCBI GeneCards UniProt Show fit	colipase
chr19_-_12887188 Show fit	27.49	ENST00000264834.6	KLF1 Ensembl NCBI GeneCards UniProt Show fit	Kruppel like factor 1
chr7_+_130380339 Show fit	26.39	ENST00000481342.5 ENST00000604896.5 ENST00000011292.8	CPA1 Ensembl NCBI GeneCards UniProt Show fit	carboxypeptidase A1
chr11_-_5249836 Show fit	26.39	ENST00000632727.1 ENST00000330597.5	HBG1 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit gamma 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	175.1	GO:0015695	organic cation transport(GO:0015695)
4.6	127.7	GO:0044241	lipid digestion(GO:0044241)
7.9	102.7	GO:0043249	erythrocyte maturation(GO:0043249)
2.0	56.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.3	42.3	GO:0046718	viral entry into host cell(GO:0046718)
1.1	35.8	GO:0006337	nucleosome disassembly(GO:0006337)
2.1	35.3	GO:0015671	oxygen transport(GO:0015671)
2.2	34.4	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.4	30.6	GO:0019730	antimicrobial humoral response(GO:0019730)
1.0	30.3	GO:1901685	glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)

Showing 1 to 10 of 307 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	335.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	214.4	GO:0005615	extracellular space(GO:0005615)
5.2	78.4	GO:0005833	hemoglobin complex(GO:0005833)
0.4	72.8	GO:0032993	protein-DNA complex(GO:0032993)
0.5	71.8	GO:0030863	cortical cytoskeleton(GO:0030863)
0.3	65.7	GO:0072562	blood microparticle(GO:0072562)
1.1	39.1	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3	31.0	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	28.9	GO:0044432	endoplasmic reticulum part(GO:0044432)
0.2	26.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)

Showing 1 to 10 of 126 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	191.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
5.2	188.3	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
4.5	67.9	GO:0005344	oxygen transporter activity(GO:0005344)
9.4	66.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
2.4	62.7	GO:0004806	triglyceride lipase activity(GO:0004806)
0.9	50.5	GO:0015485	cholesterol binding(GO:0015485)
1.0	48.6	GO:0050699	WW domain binding(GO:0050699)
0.1	44.9	GO:0000987	core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.1	42.3	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.4	40.9	GO:0005518	collagen binding(GO:0005518)

Showing 1 to 10 of 221 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	154.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8	60.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.9	43.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	40.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	36.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	24.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	21.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.3	19.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	19.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	16.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	103.1	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
1.7	69.2	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
2.4	55.9	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
1.8	52.7	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.3	48.6	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
2.5	45.5	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
1.0	34.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.8	33.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.5	31.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.3	30.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway

Showing 1 to 10 of 91 entries

Results for GATA1_GATA4

Z-value: 2.12

Motif logo

Transcription factors associated with GATA1_GATA4

Activity-expression correlation:

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: