ISMARA results: GATA2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GATA2

Z-value: 1.16

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Transcription factors associated with GATA2

Gene Symbol	Gene ID	Gene Info
GATA2 Ensembl NCBI GeneCards UniProt	ENSG00000179348.12	GATA2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA2	hg38_v1_chr3_-_128487916_128487938	-0.16	1.9e-02	Click!

Activity profile of GATA2 motif

Sorted Z-values of GATA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA2

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Promoter	Score	Transcript	Gene	Gene Info
chrX_-_19965142 Show fit	28.39	ENST00000340625.3	BCLAF3 Ensembl NCBI GeneCards UniProt Show fit	BCLAF1 and THRAP3 family member 3
chr11_-_111923722 Show fit	22.70	ENST00000527950.5	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr1_+_160115715 Show fit	22.56	ENST00000361216.8	ATP1A2 Ensembl NCBI GeneCards UniProt Show fit	ATPase Na+/K+ transporting subunit alpha 2
chr11_-_125496122 Show fit	19.59	ENST00000527534.1 ENST00000278919.8 ENST00000366139.3	FEZ1 Ensembl NCBI GeneCards UniProt Show fit	fasciculation and elongation protein zeta 1
chr5_+_36608146 Show fit	18.29	ENST00000381918.4 ENST00000513646.1	SLC1A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 member 3
chr11_-_111910830 Show fit	18.26	ENST00000526167.5 ENST00000651650.1	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr11_-_111910888 Show fit	18.20	ENST00000525823.1 ENST00000528961.6	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr16_+_55509006 Show fit	16.64	ENST00000262134.10	LPCAT2 Ensembl NCBI GeneCards UniProt Show fit	lysophosphatidylcholine acyltransferase 2
chr11_+_124739927 Show fit	16.49	ENST00000284292.11 ENST00000412681.2	NRGN Ensembl NCBI GeneCards UniProt Show fit	neurogranin
chr12_-_91179355 Show fit	16.48	ENST00000550563.5 ENST00000546370.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	69.6	GO:0007021	tubulin complex assembly(GO:0007021)
5.3	69.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3	42.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9	36.7	GO:0048665	neuron fate specification(GO:0048665)
2.2	33.4	GO:0007258	JUN phosphorylation(GO:0007258)
2.6	31.5	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1	29.5	GO:0043523	regulation of neuron apoptotic process(GO:0043523)
0.3	28.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
2.8	28.5	GO:0006537	glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.0	27.0	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)

Showing 1 to 10 of 338 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	154.2	GO:0016021	integral component of membrane(GO:0016021)
5.5	88.4	GO:0097512	cardiac myofibril(GO:0097512)
5.3	69.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	42.3	GO:0060076	excitatory synapse(GO:0060076)
3.4	27.6	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
1.8	22.8	GO:0042583	chromaffin granule(GO:0042583)
1.4	22.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3	22.0	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.9	21.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.3	21.1	GO:0043195	terminal bouton(GO:0043195)

Showing 1 to 10 of 149 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	92.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.9	74.0	GO:0050840	extracellular matrix binding(GO:0050840)
2.7	37.5	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.9	34.9	GO:0043015	gamma-tubulin binding(GO:0043015)
2.6	33.4	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	27.0	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
6.7	26.9	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1	26.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.0	25.5	GO:1990239	steroid hormone binding(GO:1990239)
0.9	25.4	GO:0043274	phospholipase binding(GO:0043274)

Showing 1 to 10 of 234 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	60.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.7	44.4	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.3	27.0	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.3	15.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	13.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	11.8	PID FGF PATHWAY	FGF signaling pathway
0.3	11.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	10.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	10.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	9.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 70 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	61.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.7	50.4	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
1.5	48.4	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.2	39.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.7	38.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
1.2	33.4	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.1	26.9	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.6	24.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	23.7	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.7	20.8	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation

Showing 1 to 10 of 94 entries

Results for GATA2

Z-value: 1.16

Motif logo

Transcription factors associated with GATA2

Activity-expression correlation:

Activity profile of GATA2 motif

Sorted Z-values of GATA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: