ISMARA results: GATA3

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for GATA3

Z-value: 1.57

Motif logo

Transcription factors associated with GATA3

Gene Symbol	Gene ID	Gene Info
GATA3 Ensembl NCBI GeneCards UniProt	ENSG00000107485.18	GATA3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA3	hg38_v1_chr10_+_8054668_8054697	-0.02	7.2e-01	Click!

Activity profile of GATA3 motif

Sorted Z-values of GATA3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA3

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr9_+_136977496 Show fit	23.69	ENST00000371625.8 ENST00000457950.5	PTGDS Ensembl NCBI GeneCards UniProt Show fit	prostaglandin D2 synthase
chr17_-_44911281 Show fit	21.94	ENST00000638304.1 ENST00000591880.2 ENST00000586125.2 ENST00000639921.1	GFAP Ensembl NCBI GeneCards UniProt Show fit	glial fibrillary acidic protein
chr2_+_90159840 Show fit	21.24	ENST00000377032.5	IGKV1D-12 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1D-12
chr12_-_91146195 Show fit	20.37	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr5_-_42825884 Show fit	19.07	ENST00000506577.5	SELENOP Ensembl NCBI GeneCards UniProt Show fit	selenoprotein P
chr5_+_151025343 Show fit	17.81	ENST00000521632.1	GPX3 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 3
chr12_-_11269696 Show fit	17.20	ENST00000381842.7	PRB3 Ensembl NCBI GeneCards UniProt Show fit	proline rich protein BstNI subfamily 3
chr8_-_27611325 Show fit	15.60	ENST00000523500.5	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr8_+_103140692 Show fit	15.27	ENST00000438105.2 ENST00000309982.10 ENST00000297574.6	BAALC Ensembl NCBI GeneCards UniProt Show fit	BAALC binder of MAP3K1 and KLF4
chr2_-_89213917 Show fit	15.05	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-27

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.5	335.7	GO:0006958	complement activation, classical pathway(GO:0006958)
5.2	67.6	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.9	53.8	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.5	52.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.5	52.5	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
2.9	49.5	GO:0007021	tubulin complex assembly(GO:0007021)
0.9	42.7	GO:0008038	neuron recognition(GO:0008038)
2.1	42.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
3.4	41.1	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
3.4	40.8	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)

Showing 1 to 10 of 875 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	300.8	GO:0031224	intrinsic component of membrane(GO:0031224)
0.2	192.6	GO:0005615	extracellular space(GO:0005615)
2.7	127.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.4	124.2	GO:0060076	excitatory synapse(GO:0060076)
0.7	107.9	GO:0072562	blood microparticle(GO:0072562)
0.3	77.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
5.3	69.5	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
4.4	66.3	GO:0097418	neurofibrillary tangle(GO:0097418)
2.5	61.5	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
3.7	58.6	GO:0097512	cardiac myofibril(GO:0097512)

Showing 1 to 10 of 249 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	218.8	GO:0003823	antigen binding(GO:0003823)
2.3	138.7	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	79.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	60.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.0	59.1	GO:0005212	structural constituent of eye lens(GO:0005212)
1.6	54.9	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.5	52.8	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
4.4	52.4	GO:0008430	selenium binding(GO:0008430)
0.3	51.5	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.4	49.7	GO:0017075	syntaxin-1 binding(GO:0017075)

Showing 1 to 10 of 547 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	65.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	64.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	52.2	NABA MATRISOME	Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins
0.7	40.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.6	36.0	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	35.2	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.2	34.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	26.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.8	24.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	23.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity

Showing 1 to 10 of 112 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	113.1	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.9	66.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
2.9	66.3	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
2.0	53.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.9	48.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.5	44.7	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.6	44.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	43.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.9	40.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.7	38.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 142 entries

Results for GATA3

Z-value: 1.57

Motif logo

Transcription factors associated with GATA3

Activity-expression correlation:

Activity profile of GATA3 motif

Sorted Z-values of GATA3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: