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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GATA6
Z-value: 0.77
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Transcription factors associated with GATA6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA6 | hg38_v1_chr18_+_22169580_22169596 | 0.03 | 6.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 33.4 | GO:0015695 | organic cation transport(GO:0015695) |
| 1.1 | 21.8 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 0.5 | 17.5 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 0.0 | 15.4 | GO:0030198 | extracellular matrix organization(GO:0030198) |
| 5.0 | 15.0 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 0.5 | 14.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 1.6 | 11.0 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) regulation of axon diameter(GO:0031133) |
| 0.9 | 10.5 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 1.6 | 9.6 | GO:0098707 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.5 | 9.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 57.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 15.6 | GO:0005615 | extracellular space(GO:0005615) |
| 2.1 | 12.5 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 11.8 | GO:0016605 | PML body(GO:0016605) |
| 0.8 | 11.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 9.8 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.7 | 9.6 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 8.5 | GO:0005768 | endosome(GO:0005768) |
| 0.1 | 7.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 7.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 36.7 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 18.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 15.4 | GO:0005178 | integrin binding(GO:0005178) |
| 5.0 | 15.0 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 0.3 | 14.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 12.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.7 | 11.6 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.4 | 11.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 1.4 | 9.8 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 3.2 | 9.6 | GO:0004998 | transferrin receptor activity(GO:0004998) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 17.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 5.8 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 5.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 4.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.8 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.5 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 22.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.4 | 18.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 18.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 17.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.4 | 7.5 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.2 | 5.9 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 5.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 4.7 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.2 | 3.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 3.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |