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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GCAGCAU
Z-value: 0.60
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miRNA associated with seed GCAGCAU
Network of associatons between targets according to the STRING database.
First level regulatory network of GCAGCAU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 2.9 | 8.7 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.2 | 6.8 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 1.4 | 5.8 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 1.4 | 5.5 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.1 | 5.3 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.7 | 5.2 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 0.2 | 4.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 1.5 | 4.5 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.6 | 4.4 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.2 | 8.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 7.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 7.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 6.5 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 6.0 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.1 | 5.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 5.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 5.3 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 4.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 2.5 | 7.6 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 7.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.6 | 7.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.6 | 6.6 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 1.9 | 5.8 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.4 | 5.8 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 1.4 | 5.5 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 1.7 | 5.2 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.1 | 5.2 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 5.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 5.2 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 4.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 4.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 3.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.4 | 8.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 7.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 6.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 5.8 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.3 | 5.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.2 | 5.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 4.1 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 3.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.6 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |