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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GCCUGUC
Z-value: 0.14
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miRNA associated with seed GCCUGUC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-214-5p
|
MIMAT0004564 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCCUGUC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_113584683 Show fit | 0.59 |
ENST00000375370.10
|
transcription factor Dp-1 |
|
| chr13_-_74133892 Show fit | 0.56 |
ENST00000377669.7
|
Kruppel like factor 12 |
|
| chr11_+_76783349 Show fit | 0.46 |
ENST00000333090.5
|
tsukushi, small leucine rich proteoglycan |
|
| chr13_+_73058993 Show fit | 0.38 |
ENST00000377687.6
|
Kruppel like factor 5 |
|
| chr22_-_50307598 Show fit | 0.37 |
ENST00000425954.1
ENST00000449103.5 ENST00000359337.9 |
plexin B2 |
|
| chr2_-_216695540 Show fit | 0.33 |
ENST00000233813.5
|
insulin like growth factor binding protein 5 |
|
| chr7_-_19117625 Show fit | 0.33 |
ENST00000242261.6
|
twist family bHLH transcription factor 1 |
|
| chrX_+_53048781 Show fit | 0.32 |
ENST00000332582.5
|
G protein-coupled receptor 173 |
|
| chr6_-_39229465 Show fit | 0.31 |
ENST00000359534.4
|
potassium two pore domain channel subfamily K member 5 |
|
| chr11_-_57515686 Show fit | 0.28 |
ENST00000533263.1
ENST00000278426.8 |
solute carrier family 43 member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.1 | 0.6 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.0 | 0.4 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.3 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.1 | 0.3 | GO:2000793 | negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) cell proliferation involved in heart valve development(GO:2000793) |
| 0.1 | 0.3 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.1 | 0.3 | GO:0035910 | N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 0.0 | 0.3 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 0.2 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.0 | 0.2 | GO:0015862 | uridine transport(GO:0015862) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 0.2 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.2 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.0 | 0.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.2 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.1 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.0 | 0.1 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.1 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.1 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.3 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 0.2 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.0 | 0.2 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 0.2 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.2 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.2 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |