ISMARA results: GCM1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCM1

Z-value: 1.03

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Transcription factors associated with GCM1

Gene Symbol	Gene ID	Gene Info
GCM1 Ensembl NCBI GeneCards UniProt	ENSG00000137270.11	GCM1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GCM1	hg38_v1_chr6_-_53148822_53148846	0.14	4.0e-02	Click!

Activity profile of GCM1 motif

Sorted Z-values of GCM1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM1

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Promoter	Score	Transcript	Gene	Gene Info
chr3_+_10164883 Show fit	32.60	ENST00000256458.5	IRAK2 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor associated kinase 2
chr22_+_22822658 Show fit	22.87	ENST00000620395.2	IGLV2-8 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-8
chr22_+_22758698 Show fit	21.54	ENST00000390312.2	IGLV2-14 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-14
chr22_+_22734577 Show fit	20.27	ENST00000390310.3	IGLV2-18 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-18
chr2_+_90069662 Show fit	20.26	ENST00000390271.2	IGKV6D-41 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6D-41 (non-functional)
chr22_+_22588155 Show fit	19.79	ENST00000390302.3	IGLV2-33 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-33 (non-functional)
chr2_-_89160329 Show fit	19.71	ENST00000390256.2	IGKV6-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6-21 (non-functional)
chr2_+_90021567 Show fit	19.70	ENST00000436451.2	IGKV6D-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6D-21 (non-functional)
chr2_-_89330429 Show fit	19.24	ENST00000620613.1	IGKV2-40 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 2-40
chr22_+_22697789 Show fit	17.74	ENST00000390306.2	IGLV2-23 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-23

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	148.4	GO:0002377	immunoglobulin production(GO:0002377)
0.9	127.3	GO:0030449	regulation of complement activation(GO:0030449)
1.4	32.6	GO:0034162	toll-like receptor 9 signaling pathway(GO:0034162)
0.8	24.8	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	18.5	GO:0002250	adaptive immune response(GO:0002250)
0.0	14.3	GO:0043547	positive regulation of GTPase activity(GO:0043547)
1.3	12.8	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.7	12.1	GO:0010960	magnesium ion homeostasis(GO:0010960)
0.1	10.6	GO:0000725	double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0	9.9	GO:0071897	DNA biosynthetic process(GO:0071897)

Showing 1 to 10 of 106 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	170.5	GO:0005615	extracellular space(GO:0005615)
0.0	74.9	GO:0005886	plasma membrane(GO:0005886)
0.1	32.5	GO:0010008	endosome membrane(GO:0010008)
1.2	24.8	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3	16.1	GO:1990391	DNA repair complex(GO:1990391)
0.1	15.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	12.8	GO:0005770	late endosome(GO:0005770)
3.4	10.2	GO:0008623	CHRAC(GO:0008623)
0.0	9.3	GO:0043235	receptor complex(GO:0043235)
0.2	8.7	GO:0042629	mast cell granule(GO:0042629)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	216.7	GO:0003823	antigen binding(GO:0003823)
0.1	38.5	GO:0046982	protein heterodimerization activity(GO:0046982)
2.3	24.8	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.3	12.8	GO:0032027	myosin light chain binding(GO:0032027)
0.7	11.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.3	10.2	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.3	9.6	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.1	9.6	GO:0004497	monooxygenase activity(GO:0004497)
0.0	9.3	GO:0008270	zinc ion binding(GO:0008270)
0.2	8.7	GO:0005184	neuropeptide hormone activity(GO:0005184)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	32.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.3	12.8	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	8.6	PID RAS PATHWAY	Regulation of Ras family activation
0.0	6.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	6.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	4.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	4.5	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	4.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	3.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	32.6	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
2.1	12.8	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	10.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	8.7	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	8.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.4	6.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	6.1	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2	5.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.3	4.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	4.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex

Showing 1 to 10 of 43 entries

Results for GCM1

Z-value: 1.03

Motif logo

Transcription factors associated with GCM1

Activity-expression correlation:

Activity profile of GCM1 motif

Sorted Z-values of GCM1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: