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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GCM2
Z-value: 0.87
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Transcription factors associated with GCM2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GCM2 | hg38_v1_chr6_-_10882037_10882048 | 0.19 | 4.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCM2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 36.7 | GO:1903296 | regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296) |
| 7.0 | 35.0 | GO:1990262 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 1.7 | 34.8 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 2.0 | 19.7 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.8 | 18.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 18.2 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 2.2 | 15.1 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.4 | 14.9 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 2.1 | 14.7 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 1.1 | 14.2 | GO:0048711 | positive regulation of astrocyte differentiation(GO:0048711) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 38.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 6.1 | 36.7 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 35.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.6 | 34.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 18.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 2.3 | 18.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 18.1 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.5 | 14.7 | GO:0005921 | gap junction(GO:0005921) |
| 1.1 | 14.2 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.9 | 12.0 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 43.6 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.7 | 35.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.5 | 18.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 15.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 1.4 | 14.2 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 13.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.5 | 13.2 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.4 | 11.3 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.0 | 9.3 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 8.7 | GO:0005516 | calmodulin binding(GO:0005516) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 38.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.8 | 34.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.4 | 22.2 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.5 | 18.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 16.4 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.2 | 14.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 8.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 6.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 6.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 5.6 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 47.6 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 1.7 | 37.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.7 | 18.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 14.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.3 | 11.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 9.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 8.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 8.0 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.3 | 7.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.3 | 6.2 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |