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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GCUACAU
Z-value: 0.36
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miRNA associated with seed GCUACAU
Network of associatons between targets according to the STRING database.
First level regulatory network of GCUACAU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_176002332 Show fit | 5.92 |
ENST00000280187.11
ENST00000512509.5 |
glycoprotein M6A |
|
| chr1_-_40665654 Show fit | 4.96 |
ENST00000372684.8
|
regulating synaptic membrane exocytosis 3 |
|
| chr12_+_12717359 Show fit | 3.46 |
ENST00000614874.2
ENST00000228872.9 |
cyclin dependent kinase inhibitor 1B |
|
| chr9_-_109167159 Show fit | 3.28 |
ENST00000561981.5
|
ferric chelate reductase 1 like |
|
| chr5_+_140966466 Show fit | 3.23 |
ENST00000615316.1
ENST00000289269.7 |
protocadherin alpha subfamily C, 2 |
|
| chr5_+_140868945 Show fit | 3.20 |
ENST00000398640.7
|
protocadherin alpha 11 |
|
| chr5_+_140841183 Show fit | 3.19 |
ENST00000378123.4
ENST00000531613.2 |
protocadherin alpha 8 |
|
| chr5_+_140848360 Show fit | 3.17 |
ENST00000532602.2
|
protocadherin alpha 9 |
|
| chr5_+_140875299 Show fit | 3.08 |
ENST00000613593.1
ENST00000398631.3 |
protocadherin alpha 12 |
|
| chr5_+_142108753 Show fit | 3.00 |
ENST00000253814.6
|
Nedd4 family interacting protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 5.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 5.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.5 | 3.5 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 3.4 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 0.7 | 3.0 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 1.0 | 2.9 | GO:0070662 | erythropoietin-mediated signaling pathway(GO:0038162) mast cell proliferation(GO:0070662) |
| 0.1 | 2.8 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.2 | 2.7 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 2.3 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 5.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 4.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.3 | 3.5 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 3.1 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.5 | 1.8 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.0 | 1.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 1.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 1.1 | GO:0070187 | telosome(GO:0070187) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 5.1 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 5.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 3.7 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 3.5 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 3.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 2.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.2 | 2.0 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 1.7 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 1.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 3.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 3.2 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.2 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 1.2 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.8 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |