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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GFI1
Z-value: 0.96
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Transcription factors associated with GFI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1 | hg38_v1_chr1_-_92483947_92483960, hg38_v1_chr1_-_92486916_92486932, hg38_v1_chr1_-_92486049_92486104 | 0.26 | 7.8e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_88857582 Show fit | 12.33 |
ENST00000390237.2
|
immunoglobulin kappa constant |
|
| chr17_-_28368012 Show fit | 12.08 |
ENST00000555059.2
|
novel protein, readthrough between VTN and SEBOX |
|
| chr11_+_72080313 Show fit | 12.05 |
ENST00000307198.11
ENST00000538413.6 ENST00000642648.1 ENST00000289488.7 |
leucine rich transmembrane and O-methyltransferase domain containing leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr17_-_69150062 Show fit | 10.72 |
ENST00000522787.5
ENST00000521538.5 |
ATP binding cassette subfamily A member 10 |
|
| chr11_+_72080803 Show fit | 10.30 |
ENST00000423494.6
ENST00000539587.6 ENST00000536917.2 ENST00000538478.5 ENST00000324866.11 ENST00000643715.1 ENST00000439209.5 |
leucine rich transmembrane and O-methyltransferase domain containing leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr11_+_72080595 Show fit | 9.72 |
ENST00000647530.1
ENST00000539271.6 ENST00000642510.1 |
leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr6_+_6588708 Show fit | 9.53 |
ENST00000230568.5
|
lymphocyte antigen 86 |
|
| chr6_+_31982057 Show fit | 9.03 |
ENST00000428956.7
ENST00000498271.1 |
complement C4A (Rodgers blood group) |
|
| chr6_+_32014795 Show fit | 8.96 |
ENST00000435363.7
ENST00000425700.3 |
complement C4B (Chido blood group) |
|
| chr11_-_117877463 Show fit | 8.89 |
ENST00000527717.5
|
FXYD domain containing ion transport regulator 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 32.1 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 1.6 | 18.0 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.2 | 17.3 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.1 | 16.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.4 | 16.6 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 0.0 | 15.9 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.1 | 14.5 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.3 | 14.0 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
| 0.3 | 13.0 | GO:0048665 | neuron fate specification(GO:0048665) |
| 1.4 | 12.9 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 119.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 34.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 20.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 18.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 17.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 14.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 12.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 12.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 12.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 10.6 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.6 | 32.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 22.0 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.9 | 19.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.4 | 16.6 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.0 | 15.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.7 | 13.4 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 12.9 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 12.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.7 | 11.9 | GO:0001849 | complement component C1q binding(GO:0001849) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 17.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 17.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 16.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 10.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 10.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 8.9 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 7.7 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 6.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 6.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 22.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 16.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 14.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 13.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 12.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 9.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.5 | 9.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 8.8 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.3 | 8.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |