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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GFI1B
Z-value: 0.92
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Transcription factors associated with GFI1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1B | hg38_v1_chr9_+_132978687_132978772 | -0.45 | 2.4e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 29.1 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 21.5 | GO:0003012 | muscle system process(GO:0003012) |
| 3.7 | 18.5 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 3.5 | 17.7 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 4.3 | 17.1 | GO:0002188 | translation reinitiation(GO:0002188) |
| 1.4 | 16.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.3 | 15.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.6 | 13.3 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 1.6 | 12.9 | GO:0006561 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 1.2 | 11.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 26.2 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 25.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 3.1 | 18.5 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.2 | 17.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 3.3 | 16.6 | GO:0031673 | H zone(GO:0031673) |
| 2.1 | 16.6 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 16.1 | GO:0001726 | ruffle(GO:0001726) |
| 0.3 | 13.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 11.5 | GO:0005694 | chromosome(GO:0005694) |
| 0.7 | 11.1 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 23.3 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.8 | 20.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 2.3 | 18.5 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.0 | 16.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 15.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 15.2 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 14.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.5 | 13.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 13.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.7 | 13.1 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 16.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 13.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 10.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 9.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 8.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.3 | 8.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 7.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.4 | 7.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 6.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 20.6 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.5 | 12.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 11.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 10.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.3 | 9.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 9.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 9.4 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.1 | 8.8 | REACTOME PI METABOLISM | Genes involved in PI Metabolism |
| 0.4 | 8.4 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |