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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GGAAUGU
Z-value: 1.52
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miRNA associated with seed GGAAUGU
Network of associatons between targets according to the STRING database.
First level regulatory network of GGAAUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.6 | 77.8 | GO:0019322 | pentose biosynthetic process(GO:0019322) |
| 3.3 | 43.2 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 3.2 | 42.1 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 6.5 | 32.5 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 1.5 | 28.4 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 1.6 | 28.3 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 2.0 | 28.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.7 | 26.9 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 4.4 | 26.6 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.8 | 25.5 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 107.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 97.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 76.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 56.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.6 | 42.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 2.5 | 37.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.5 | 33.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.4 | 32.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 30.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.5 | 28.7 | GO:0031519 | PcG protein complex(GO:0031519) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 49.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.5 | 43.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 36.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.9 | 36.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.5 | 35.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 2.0 | 27.8 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 1.7 | 26.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 26.5 | GO:0003723 | RNA binding(GO:0003723) |
| 8.6 | 25.8 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 6.4 | 25.8 | GO:0004802 | transketolase activity(GO:0004802) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 42.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 40.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.8 | 39.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.3 | 36.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.2 | 34.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.7 | 32.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.5 | 28.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.5 | 27.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.4 | 26.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 24.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 67.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 54.4 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.3 | 34.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 29.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 29.4 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 1.1 | 28.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.4 | 27.0 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.9 | 26.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 25.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.4 | 24.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |