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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GGCAGUG
Z-value: 0.91
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miRNA associated with seed GGCAGUG
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCAGUG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 31.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 5.6 | 28.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 8.4 | 25.3 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.4 | 21.8 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 1.7 | 19.9 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 4.6 | 13.7 | GO:0051946 | regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920) |
| 1.2 | 13.4 | GO:0071205 | protein localization to juxtaparanode region of axon(GO:0071205) |
| 2.7 | 13.3 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 4.3 | 13.0 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 3.2 | 13.0 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 36.6 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 5.1 | 25.3 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 25.2 | GO:0030425 | dendrite(GO:0030425) |
| 1.2 | 19.9 | GO:0005883 | neurofilament(GO:0005883) |
| 0.1 | 16.3 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.2 | 15.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.7 | 15.0 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.8 | 14.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.4 | 13.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.8 | 13.4 | GO:0033010 | paranodal junction(GO:0033010) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 38.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 35.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.2 | 26.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 5.1 | 25.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.4 | 23.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 19.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 18.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.7 | 15.4 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 1.1 | 14.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 3.4 | 13.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.6 | 17.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 10.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 9.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 9.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 8.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.5 | 8.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 7.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 6.7 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 61.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 22.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.6 | 21.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 17.2 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.7 | 14.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 14.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 13.3 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 11.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 9.0 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 8.6 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |