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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GGCUCAG
Z-value: 0.98
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miRNA associated with seed GGCUCAG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-24-3p
|
MIMAT0000080 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCUCAG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 17.5 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.4 | 14.7 | GO:0060384 | innervation(GO:0060384) |
| 4.8 | 14.4 | GO:0072277 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.5 | 11.9 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 3.8 | 11.5 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.2 | 11.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 2.7 | 10.7 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 2.0 | 10.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.3 | 10.0 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 1.9 | 9.7 | GO:0097167 | circadian regulation of translation(GO:0097167) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 38.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 29.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.2 | 17.5 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.4 | 14.2 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 1.7 | 13.6 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 1.0 | 12.1 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 10.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 2.5 | 10.1 | GO:0035363 | histone locus body(GO:0035363) |
| 0.1 | 9.4 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 9.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.8 | 14.4 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.1 | 14.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 13.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 11.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 10.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 10.7 | GO:0043621 | protein self-association(GO:0043621) |
| 0.2 | 10.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 10.1 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.1 | 9.4 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 15.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 14.6 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 12.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 12.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.6 | 11.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 9.5 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 6.5 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 6.5 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.3 | 6.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 12.1 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.2 | 11.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.5 | 11.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 9.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.4 | 8.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 8.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.4 | 7.4 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 7.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.4 | 7.1 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |