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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GLI2
Z-value: 1.38
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Transcription factors associated with GLI2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI2 | hg38_v1_chr2_+_120735848_120735899 | -0.64 | 3.3e-26 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 60.0 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.6 | 54.8 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 5.2 | 47.1 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 4.4 | 43.6 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 3.3 | 42.5 | GO:0043248 | proteasome assembly(GO:0043248) |
| 3.5 | 41.6 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 3.2 | 41.5 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 2.6 | 34.3 | GO:0010528 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) |
| 8.0 | 32.0 | GO:0009216 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) |
| 0.4 | 28.3 | GO:0006953 | acute-phase response(GO:0006953) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 62.1 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.6 | 49.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 1.8 | 47.1 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 2.8 | 45.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.3 | 44.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 2.7 | 43.6 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.1 | 38.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.7 | 37.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.9 | 36.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 8.3 | 33.3 | GO:0008537 | proteasome activator complex(GO:0008537) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 72.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 11.8 | 58.9 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 2.2 | 47.1 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.3 | 47.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 2.8 | 45.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 10.9 | 43.6 | GO:0047676 | arachidonate-CoA ligase activity(GO:0047676) |
| 1.8 | 42.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 5.1 | 40.8 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 7.1 | 35.4 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 5.9 | 35.3 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 100.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.2 | 59.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.6 | 46.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.4 | 38.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.5 | 37.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.5 | 36.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.6 | 36.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 33.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.5 | 31.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 1.5 | 30.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 94.7 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 2.2 | 72.8 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 3.0 | 68.9 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 2.4 | 51.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 1.5 | 47.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.3 | 37.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 32.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 1.3 | 32.0 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 1.0 | 30.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 28.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |